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Dr Gemma Sharp

Associate Professor in Reproductive and Mental Health Epidemiology

 Washington Singer 117

 

Washington Singer Laboratories, University of Exeter, Perry Road, Prince of Wales Road, Exeter, EX4 4QG, UK

 Office hours:

1 to 3 Mondays and Fridays. Please email me to arrange to chat.

Overview

I’m an Associate Professor in the School of Psychology at the University of Exeter, where I research and teach about women’s mental health, reproductive health, and early life influences on health and wellbeing.

I was born in Bristol and grew up a few miles south in Nailsea. I did my undergraduate BSc in Biology at Cardiff University, then my MSc in Reproduction and Development at the University of Bristol, and my PhD in Reproductive Health at the MRC Centre for Reproductive Health at the University of Edinburgh. Prior to working in Exeter, I worked for nine years as a postdoc, lecturer and senior lecturer at the MRC Integrative Epidemiology Unit at the University of Bristol.

Qualifications

PhD Reproductive Biology - University of Edinburgh

MSc Reproduction and Development - University of Bristol

BSc Biology - Cardiff University

Links

Research group links

Research

Research interests

You can find a list of all my reseach outputs here.

I’m interested in addressing important contemporary questions around the health and wellbeing of women and young people. To do this, I use population-level “big data”, including data on genetics and epigenetics (i.e. “molecular” epidemiology).

Women’s reproductive health

The menstrual cycle and menstrual health
I established the Menarche, Menstruation, Menopause and Mental Health (4M) consortium to facilitate collaborative research into how the menstrual cycle interacts with mental health. This association is likely to be extremely complex and multidirectional, involving interactions between genetics, reproductive hormones and other physiological processes, but also environmental factors including lifestyle and social, political and structural influences on health and wellbeing.

Pregnancy health
My PhD was entitled Comprehensive data analysis to study parturition (“parturition” = childbirth). Since my PhD, I’ve been involved with several studies of pregnancy complications, including gestational diabetes and pre-eclampsia.

Early life and prenatal influences on child and adult health

I’m interested in how our early environments and experiences can shape our health and wellbeing into adulthood.

DOHaD
Traditionally, research on the developmental origins of health and disease (DOHaD) has focused on the influence of the lifestyle of pregnant women on the health of their children. Although much of the evidence has been correlative (rather than showing robust causal effects), it has been used to back up public health policies and clinical practices that seek to change pregnant women’s behaviour. Through my research, I have tried to improve the causal evidence base in DOHaD by studying potentially causal biological mechanisms and using genetic and statistical approaches to infer causality. I have also tried to expand the traditional focus on pregnant women to study paternal factors and the wider social determinants of health as well.

Cleft lip and/or palate
Some of my research has focused more specifically on particular conditions in children; exploring the early-life causes of these conditions, as well as the consequences. Most notably, I’m a key member of the Cleft Collective research team at the University of Bristol, where I’ve led research on the epidemiology of cleft lip and/or palate.

Research projects

My main research projects and activities include:

  • Menarche, Menstruation, Menopause and Mental Health (4M)
  • Exploring Prenatal influences on Child Health (EPoCH)
  • Understanding and improving mental health and neurodevelopment in children born with a cleft lip/palate

 

Research networks

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (In Press). Genomic and phenomic insights from an atlas of genetic effects on DNA methylation.  Abstract.
Clarke SLN, Richmond RC, Zheng J, Spiller W, Ramanan AV, Sharp GC, Relton CL (2022). Examining Health Outcomes in Juvenile Idiopathic Arthritis: a Genetic Epidemiology Study. ACR Open Rheumatol, 4(4), 363-370. Abstract.  Author URL.
Sammallahti S, Koopman-Verhoeff ME, Binter A-C, Mulder RH, Cabré-Riera A, Kvist T, Malmberg ALK, Pesce G, Plancoulaine S, Heiss JA, et al (2022). Longitudinal associations of DNA methylation and sleep in children: a meta-analysis. Clin Epigenetics, 14(1). Abstract.  Author URL.
Küpers LK, Fernández-Barrés S, Mancano G, Johnson L, Ott R, Vioque J, Colombo M, Landgraf K, Tobi EW, Körner A, et al (2022). Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation. Diabetes Care, 45(8), 1822-1832. Abstract.  Author URL.
Küpers LK, Fernández-Barrés S, Nounu A, Friedman C, Fore R, Mancano G, Dabelea D, Rifas-Shiman SL, Mulder RH, Oken E, et al (2022). Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium. Epigenetics, 17(11), 1419-1431. Abstract.
Tran C, Crawford AA, Hamilton A, French CE, Wren Y, Sandy J, Sharp G (2022). Maternal Stressful Life Events During the Periconceptional Period and Orofacial Clefts: a Systematic Review and Meta-Analysis. Cleft Palate Craniofac J, 59(10), 1253-1263. Abstract.  Author URL.
Taeubert MJ, de Prado-Bert P, Geurtsen ML, Mancano G, Vermeulen MJ, Reiss IKM, Caramaschi D, Sunyer J, Sharp GC, Julvez J, et al (2022). Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis. CLINICAL EPIGENETICS, 14(1). Author URL.
Solomon O, Huen K, Yousefi P, Küpers LK, González JR, Suderman M, Reese SE, Page CM, Gruzieva O, Rzehak P, et al (2022). Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation. Mutation Research - Reviews in Mutation Research, 789 Abstract.
Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, et al (2022). Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills. Molecular Psychiatry, 27(4), 2126-2135. Abstract.
Clarke SLN, Mageean KS, Maccora I, Harrison S, Simonini G, Sharp GC, Relton CL, Ramanan AV (2022). Moving from nature to nurture: a systematic review and meta-analysis of environmental factors associated with juvenile idiopathic arthritis. Rheumatology (United Kingdom), 61(2), 514-530. Abstract.
Sharp GC, Fraser A, Sawyer G, Kountourides G, Easey KE, Ford G, Olszewska Z, Howe LD, Lawlor DA, Alvergne A, et al (2022). The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities. Int J Epidemiol, 51(3), 691-700. Author URL.
Battram T, Yousefi P, Crawford G, Prince C, Sheikhali Babaei M, Sharp G, Hatcher C, Vega-Salas MJ, Khodabakhsh S, Whitehurst O, et al (2022). The EWAS Catalog: a database of epigenome-wide association studies. Wellcome Open Research, 7 Abstract.
Battram T, Yousefi P, Crawford G, Prince C, Sheikhali Babaei M, Sharp G, Hatcher C, Vega-Salas MJ, Khodabakhsh S, Whitehurst O, et al (2022). The EWAS Catalog: a database of epigenome-wide association studies. Wellcome Open Res, 7 Abstract.  Author URL.
Prince C, Sharp GC, Howe LD, Fraser A, Richmond RC (2022). The relationships between women’s reproductive factors: a Mendelian randomisation analysis. BMC Medicine, 20(1). Abstract.
Juvinao-Quintero DL, Marioni RE, Ochoa-Rosales C, Russ TC, Deary IJ, van Meurs JBJ, Voortman T, Hivert MF, Sharp GC, Relton CL, et al (2021). DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts. Clinical Epigenetics, 13(1). Abstract.
Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (2021). Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nat Genet, 53(9), 1311-1321. Abstract.  Author URL.
Richmond RC, Sillero-Rejon C, Khouja JN, Prince C, Board A, Sharp G, Suderman M, Relton CL, Munafò M, Gage SH, et al (2021). Investigating the DNA methylation profile of e-cigarette use. Clin Epigenetics, 13(1). Abstract.  Author URL.
Schellhas L, Haan E, Easey KE, Wootton RE, Sallis HM, Sharp GC, Munafò MR, Zuccolo L (2021). Maternal and child genetic liability for smoking and caffeine consumption and child mental health: an intergenerational genetic risk score analysis in the ALSPAC cohort. Addiction, 116(11), 3153-3166. Abstract.
Sammallahti S, Cortes Hidalgo AP, Tuominen S, Malmberg A, Mulder RH, Brunst KJ, Alemany S, McBride NS, Yousefi P, Heiss JA, et al (2021). Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation. MOLECULAR PSYCHIATRY, 26(6), 1832-1845. Author URL.
Sharp GC, Alfano R, Ghantous A, Urquiza J, Rifas-Shiman SL, Page CM, Jin J, Fernández-Barrés S, Santorelli G, Tindula G, et al (2021). Paternal body mass index and offspring DNA methylation: Findings from the PACE consortium. International Journal of Epidemiology, 50(4), 1297-1315. Abstract.
Easey KE, Sharp GC (2021). The impact of paternal alcohol, tobacco, caffeine use and physical activity on offspring mental health: a systematic review and meta-analysis. Reproductive Health, 18(1). Abstract.
Clarke SL, Mitchell RE, Sharp GC, Ramanan AV, Relton CL (2021). Vitamin D levels and risk of juvenile idiopathic arthritis: a Mendelian randomization study. Arthritis Care Res (Hoboken) Abstract.  Author URL.
Clarke SLN, Mageean KS, Carlton H, Simonini G, Sharp GC, Relton CL, Ramanan AV (2021). “Environmental risk factors associated with juvenile idiopathic arthritis associated uveitis: a systematic review of the literature”. Journal of Ophthalmic Inflammation and Infection, 11(1). Abstract.
Neumann A, Walton E, Alemany S, Cecil C, Gonzalez JR, Jima DD, Lahti J, Tuominen ST, Barker ED, Binder E, et al (2020). Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis. TRANSLATIONAL PSYCHIATRY, 10(1). Author URL.
Dardani C, Howe LJ, Mukhopadhyay N, Stergiakouli E, Wren Y, Humphries K, Davies A, Ho K, Weinberg SM, Marazita ML, et al (2020). Cleft lip/palate and educational attainment: Cause, consequence or correlation? a Mendelian randomization study. International Journal of Epidemiology, 49(4), 1282-1293. Abstract.
Griffith GJ, Morris TT, Tudball MJ, Herbert A, Mancano G, Pike L, Sharp GC, Sterne J, Palmer TM, Davey Smith G, et al (2020). Collider bias undermines our understanding of COVID-19 disease risk and severity. Nature Communications, 11(1). Abstract.
Vehmeijer FOL, Küpers LK, Sharp GC, Salas LA, Lent S, Jima DD, Tindula G, Reese S, Qi C, Gruzieva O, et al (2020). DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies. Genome Medicine, 12(1). Abstract.
Merid SK, Novoloaca A, Sharp GC, Küpers LK, Kho AT, Roy R, Gao L, Annesi-Maesano I, Jain P, Plusquin M, et al (2020). Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age. Genome Medicine, 12(1). Abstract.
Howe CG, Cox B, Fore R, Jungius J, Kvist T, Lent S, Miles HE, Salas LA, Rifas-Shiman S, Starling AP, et al (2020). Maternal gestational diabetes mellitus and newborn DNA Methylation: Findings from the pregnancy and childhood epigenetics consortium. Diabetes Care, 43(1), 98-105. Abstract.
Sharp G, Schellhas L, Richardson S, Lawlor D (2020). Time to cut the cord: recognizing and addressing the imbalance of DOHaD research towards the study of maternal pregnancy exposures - CORRIGENDUM. J Dev Orig Health Dis, 11(1). Author URL.
Richardson TG, Richmond RC, North TL, Hemani G, Davey Smith G, Sharp GC, Relton CL (2019). An integrative approach to detect epigenetic mechanisms that putatively mediate the influence of lifestyle exposures on disease susceptibility. International Journal of Epidemiology, 48(3), 887-898. Abstract.
Juvinao-Quintero DL, Hivert M-F, Sharp GC, Relton CL, Elliott HR (2019). DNA Methylation and Type 2 Diabetes: the Use of Mendelian Randomization to Assess Causality. Curr Genet Med Rep, 7(4), 191-207. Abstract.  Author URL.
Elliott HR, Sharp GC, Relton CL, Lawlor DA (2019). Epigenetics and gestational diabetes: a review of epigenetic epidemiology studies and their use to explore epigenetic mediation and improve prediction. Diabetologia, 62(12), 2171-2178. Abstract.
Everson TM, Zhang H, Lockett GA, Kaushal A, Forthofer M, Ewart SL, Burrows K, Relton CL, Sharp GC, Henderson AJ, et al (2019). Epigenome-wide association study of asthma and wheeze characterizes loci within HK1. Allergy, Asthma and Clinical Immunology, 15(1), 1-12. Abstract.
Imboden M, Wielscher M, Rezwan FI, Amaral AFS, Schaffner E, Jeong A, Beckmeyer-Borowko A, Harris SE, Starr JM, Deary IJ, et al (2019). Epigenome-wide association study of lung function level and its change. European Respiratory Journal, 54(1). Abstract.
Reese SE, Xu CJ, den Dekker HT, Lee MK, Sikdar S, Ruiz-Arenas C, Merid SK, Rezwan FI, Page CM, Ullemar V, et al (2019). Epigenome-wide meta-analysis of DNA methylation and childhood asthma. Journal of Allergy and Clinical Immunology, 143(6), 2062-2074. Abstract.
Howe LJ, Richardson TG, Arathimos R, Alvizi L, Passos-Bueno MR, Stanier P, Nohr E, Ludwig KU, Mangold E, Knapp M, et al (2019). Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate. Epigenomics, 11(2), 133-145. Abstract.
Timms JA, Relton CL, Sharp GC, Rankin J, Strathdee G, McKay JA (2019). Exploring a potential mechanistic role of DNA methylation in the relationship between in utero and post-natal environmental exposures and risk of childhood acute lymphoblastic leukaemia. International Journal of Cancer, 145(11), 2933-2943. Abstract.
Kazmi N, Sharp GC, Reese SE, Vehmeijer FO, Lahti J, Page CM, Zhang W, Rifas-Shiman SL, Rezwan FI, Simpkin AJ, et al (2019). Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns: Findings from the Pregnancy and Childhood Epigenetics Consortium. Hypertension, 74(2), 375-383. Abstract.
Martin CL, Jima D, Sharp GC, McCullough LE, Park SS, Gowdy KM, Skaar D, Cowley M, Maguire RL, Fuemmeler B, et al (2019). Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study. Epigenetics, 14(4), 325-340. Abstract.
Küpers LK, Monnereau C, Sharp GC, Yousefi P, Salas LA, Ghantous A, Page CM, Reese SE, Wilcox AJ, Czamara D, et al (2019). Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. Nature Communications, 10(1). Abstract.
den Dekker HT, Burrows K, Felix JF, Salas LA, Nedeljkovic I, Yao J, Rifas-Shiman SL, Ruiz-Arenas C, Amin N, Bustamante M, et al (2019). Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course. European Respiratory Journal, 53(4). Abstract.
Sharp GC, Lawlor DA (2019). Paternal impact on the life course development of obesity and type 2 diabetes in the offspring. Diabetologia, 62(10), 1802-1810. Abstract.
Howe LJ, Sharp GC, Hemani G, Zuccolo L, Richmond S, Lewis SJ (2019). Prenatal alcohol exposure and facial morphology in a UK cohort. Drug and Alcohol Dependence, 197, 42-47. Abstract.
Sharp GC, Schellhas L, Richardson SS, Lawlor DA (2019). Time to cut the cord: Recognizing and addressing the imbalance of DOHaD research towards the study of maternal pregnancy exposures. Journal of Developmental Origins of Health and Disease, 10(5), 509-512.
Ambatipudi S, Sharp GC, Clarke SLN, Plant D, Tobias JH, Evans DM, Barton A, Relton CL (2018). Assessing the role of DNA methylation-derived neutrophil-to-lymphocyte ratio in rheumatoid arthritis. Journal of Immunology Research, 2018 Abstract.
Arathimos R, Sharp GC, Granell R, Tilling K, Relton CL (2018). Associations of sex hormone-binding globulin and testosterone with genome-wide DNA methylation 06 Biological Sciences 0604 Genetics. BMC Genetics, 19(1). Abstract.
Felix JF, Joubert BR, Baccarelli AA, Sharp GC, Almqvist C, Annesi-Maesano I, Arshad H, Baiz N, Bakermans-Kranenburg MJ, Bakulski KM, et al (2018). Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium. International Journal of Epidemiology, 47(1), 22-23u.
Sharp GC, Stergiakouli E, Sandy J, Relton C (2018). Epigenetics and Orofacial Clefts: a Brief Introduction. Cleft Palate-Craniofacial Journal, 55(6), 795-797.
Howe LJ, Lee MK, Sharp GC, Davey Smith G, St Pourcain B, Shaffer JR, Ludwig KU, Mangold E, Marazita ML, Feingold E, et al (2018). Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology. PLoS Genetics, 14(8). Abstract.
Sharp GC, Lawlor DA, Richardson SS (2018). It's the mother!: How assumptions about the causal primacy of maternal effects influence research on the developmental origins of health and disease. Social Science and Medicine, 213, 20-27. Abstract.
Sharp GC, Arathimos R, Reese SE, Page CM, Felix J, Küpers LK, Rifas-Shiman SL, Liu C, Burrows K, Zhao S, et al (2018). Maternal alcohol consumption and offspring DNA methylation: Findings from six general population-based birth cohorts. Epigenomics, 10(1), 27-42. Abstract.
Viuff AC, Sharp GC, Rai D, Henriksen TB, Pedersen LH, Kyng KJ, Staunstrup NH, Cortes A, Neumann A, Felix JF, et al (2018). Maternal depression during pregnancy and cord blood DNA methylation: findings from the Avon Longitudinal Study of Parents and Children. Translational Psychiatry, 8(1). Abstract.
Xiong Z, Zhou H, Dankova G, Howe LJ, Lee MK, Hysi PG, de Jong MA, Zhu G, Adhikari K, Li D, et al (2018). Novel Genetic Loci Affecting Facial Shape Variation in Humans.
Beckmeyer-Borowko A, Imboden M, Rezwan FI, Wielscher M, Amaral AFS, Jeong A, Schaffner E, Auvinen J, Sebert S, Karhunen V, et al (2018). SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts. Respiratory Research, 19(1). Abstract.
Richmond RC, Sharp GC, Herbert G, Atkinson C, Taylor C, Bhattacharya S, Campbell D, Hall M, Kazmi N, Gaunt T, et al (2018). The long-term impact of folic acid in pregnancy on offspring DNA methylation: Follow-up of the Aberdeen folic acid supplementation trial (AFAST). International Journal of Epidemiology, 47(3), 928-937. Abstract.
Sharp GC, Ho K, Davies A, Stergiakouli E, Humphries K, McArdle W, Sandy J, Davey Smith G, Lewis SJ, Relton CL, et al (2017). Distinct DNA methylation profiles in subtypes of orofacial cleft. Clinical Epigenetics, 9(1). Abstract.
Sharp GC, Relton CL (2017). Epigenetics and noncommunicable diseases. Epigenomics, 9(6), 789-791.
Arathimos R, Suderman M, Sharp GC, Burrows K, Granell R, Tilling K, Gaunt TR, Henderson J, Ring S, Richmond RC, et al (2017). Epigenome-wide association study of asthma and wheeze in childhood and adolescence. Clinical Epigenetics, 9(1). Abstract.
Caramaschi D, Sharp GC, Nohr EA, Berryman K, Lewis SJ, Smith GD, Relton CL (2017). Exploring a causal role of DNA methylation in the relationship between maternal vitamin B-12 during pregnancy and child's IQ at age 8, cognitive performance and educational attainment: a two-step Mendelian randomization study. HUMAN MOLECULAR GENETICS, 26(15), 3001-3013. Author URL.
Sharp GC, Salas LA, Monnereau C, Allard C, Yousefi P, Everson TM, Bohlin J, Xu Z, Huang RC, Reese SE, et al (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics, 26(20), 4067-4085. Abstract.
Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese SE, Markunas CA, Richmond RC, Xu CJ, et al (2016). DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. American Journal of Human Genetics, 98(4), 680-696. Abstract.
Richmond RC, Sharp GC, Ward ME, Fraser A, Lyttleton O, McArdle WL, Ring SM, Gaunt TR, Lawlor DA, Smith GD, et al (2016). DNA methylation and BMI: Investigating identified methylation sites at HIF3A in a causal framework. Diabetes, 65(5), 1231-1244. Abstract.
Simpkin AJ, Hemani G, Suderman M, Gaunt TR, Lyttleton O, Mcardle WL, Ring SM, Sharp GC, Tilling K, Horvath S, et al (2016). Prenatal and early life influences on epigenetic age in children: a study of mother-offspring pairs from two cohort studies. Human Molecular Genetics, 25(1), 191-201. Abstract.
Sharp GC, Hutchinson JL, Hibbert N, Freeman TC, Saunders PTK, Norman JE (2016). Transcription analysis of the myometrium of labouring and non-labouring women. PLoS ONE, 11(5). Abstract.
Sharp GC, Lawlor DA, Richmond RC, Fraser A, Simpkin A, Suderman M, Shihab HA, Lyttleton O, McArdle W, Ring SM, et al (2015). Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: Findings from the Avon Longitudinal Study of Parents and Children. International Journal of Epidemiology, 44(4), 1288-1304. Abstract.
Sharp GC, Stock SJ, Norman JE (2014). Fetal assessment methods for improving neonatal and maternal outcomes in preterm prelabour rupture of membranes. Cochrane Database of Systematic Reviews, 2014(10). Abstract.
Sharp GC, Saunders PTK, Greene SA, Morris AD, Norman JE (2014). Intergenerational transmission of postpartum hemorrhage risk: Analysis of 2 Scottish birth cohorts. American Journal of Obstetrics and Gynecology, 211(1), 51.e1-51.e7. Abstract.
Sharp GC, Ma H, Saunders PTK, Norman JE (2013). A Computational Model of Lipopolysaccharide-Induced Nuclear Factor Kappa B Activation: a Key Signalling Pathway in Infection-Induced Preterm Labour. PLoS ONE, 8(7). Abstract.
Sharp GC, Saunders PTK, Norman JE (2013). Computer models to study uterine activation at labour. Molecular Human Reproduction, 19(11), 711-717. Abstract.

Chapters

Sharp GC, Stock SJ, Norman JE (2012). Fetal assessment methods for improving neonatal and maternal outcomes in preterm prelabour rupture of membranes. In  (Ed) Cochrane Database of Systematic Reviews.

Conferences

Prince C, Sharp GC, Howe LD, Fraser A, Richmond RC (2021). INVESTIGATING CAUSALITY BETWEEN ADIPOSITY AND WOMEN'S REPRODUCTIVE FACTORS: a MENDELIAN RANDOMIZATION ANALYSIS.  Author URL.
Martin FZ, Easey KE, Howe LD, Lawlor DA, Fraser A, Relton CL, Sharp GC (2021). NOVEL RISK FACTORS FOR MENORRHAGIA AND DYSMENORRHEA IN ADOLESCENCE USING THE ALSPAC COHORT.  Author URL.
Easey K, Sharp G (2021). USING DATA ON FATHERS/PARTNERS TO STUDY PRENATAL PARENTAL EXPOSURES AND CHILD HEALTH: CHALLENGES INTRODUCED BY MISSING DATA AND SELECTION BIAS.  Author URL.
Schellhas L, Lou M, Monasso G, Fernandez Barres S, Pesce G, Maesano IA, Page C, London S, Cecil C, Felix J, et al (2020). The epigenome as a biological pathway of the effects of prenatal exposure to tobacco, alcohol, and caffeine on childhood internalising problems in offspring: two large multi-cohort epigenome-wide association studies.  Author URL.
Staunstrup N, Viuff A-C, Sharp G, Pedersen L, Kyng K, Rai D, Relton C, Henriksen T (2019). EPIGENETIC DIFFERENCES IN CORD BLOOD OF NEWBORNS EXPOSED TO ANTIDEPRESSANT MEDICATION DURING PREGNANCY - a STUDY IN THE AARHUS BIRTH COHORT.  Author URL.
Arathimos R, Suderman M, Sharp G, Burrows K, Granell R, Tilling K, Richmond R, Haycock P, Relton C (2017). Epigenome-wide association study of asthma and wheeze in childhood and adolescence.  Author URL.
Sharp G, Freeman T, Saunders P, Norman J (2013). A NOVEL NETWORK GRAPH APPROACH FOR THE ANALYSIS AND VISUALISATION OF EPIDEMIOLOGICAL DATA.  Author URL.

Publications by year


In Press

Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (In Press). Genomic and phenomic insights from an atlas of genetic effects on DNA methylation.  Abstract.

2022

Clarke SLN, Richmond RC, Zheng J, Spiller W, Ramanan AV, Sharp GC, Relton CL (2022). Examining Health Outcomes in Juvenile Idiopathic Arthritis: a Genetic Epidemiology Study. ACR Open Rheumatol, 4(4), 363-370. Abstract.  Author URL.
Juvinao-Quintero D, Sharp G, Sanderson E, Relton C, Elliott H (2022). Investigating causality in the association between DNA methylation and prevalent T2D using a bidirectional two-sample Mendelian Randomization.  Abstract.
Sammallahti S, Koopman-Verhoeff ME, Binter A-C, Mulder RH, Cabré-Riera A, Kvist T, Malmberg ALK, Pesce G, Plancoulaine S, Heiss JA, et al (2022). Longitudinal associations of DNA methylation and sleep in children: a meta-analysis. Clin Epigenetics, 14(1). Abstract.  Author URL.
Küpers LK, Fernández-Barrés S, Mancano G, Johnson L, Ott R, Vioque J, Colombo M, Landgraf K, Tobi EW, Körner A, et al (2022). Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation. Diabetes Care, 45(8), 1822-1832. Abstract.  Author URL.
Küpers LK, Fernández-Barrés S, Nounu A, Friedman C, Fore R, Mancano G, Dabelea D, Rifas-Shiman SL, Mulder RH, Oken E, et al (2022). Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium. Epigenetics, 17(11), 1419-1431. Abstract.
Tran C, Crawford AA, Hamilton A, French CE, Wren Y, Sandy J, Sharp G (2022). Maternal Stressful Life Events During the Periconceptional Period and Orofacial Clefts: a Systematic Review and Meta-Analysis. Cleft Palate Craniofac J, 59(10), 1253-1263. Abstract.  Author URL.
Taeubert MJ, de Prado-Bert P, Geurtsen ML, Mancano G, Vermeulen MJ, Reiss IKM, Caramaschi D, Sunyer J, Sharp GC, Julvez J, et al (2022). Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis. CLINICAL EPIGENETICS, 14(1). Author URL.
Solomon O, Huen K, Yousefi P, Küpers LK, González JR, Suderman M, Reese SE, Page CM, Gruzieva O, Rzehak P, et al (2022). Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation. Mutation Research - Reviews in Mutation Research, 789 Abstract.
Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, et al (2022). Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills. Molecular Psychiatry, 27(4), 2126-2135. Abstract.
Clarke SLN, Mageean KS, Maccora I, Harrison S, Simonini G, Sharp GC, Relton CL, Ramanan AV (2022). Moving from nature to nurture: a systematic review and meta-analysis of environmental factors associated with juvenile idiopathic arthritis. Rheumatology (United Kingdom), 61(2), 514-530. Abstract.
Sharp GC, Fraser A, Sawyer G, Kountourides G, Easey KE, Ford G, Olszewska Z, Howe LD, Lawlor DA, Alvergne A, et al (2022). The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities. Int J Epidemiol, 51(3), 691-700. Author URL.
Battram T, Yousefi P, Crawford G, Prince C, Sheikhali Babaei M, Sharp G, Hatcher C, Vega-Salas MJ, Khodabakhsh S, Whitehurst O, et al (2022). The EWAS Catalog: a database of epigenome-wide association studies. Wellcome Open Research, 7 Abstract.
Battram T, Yousefi P, Crawford G, Prince C, Sheikhali Babaei M, Sharp G, Hatcher C, Vega-Salas MJ, Khodabakhsh S, Whitehurst O, et al (2022). The EWAS Catalog: a database of epigenome-wide association studies. Wellcome Open Res, 7 Abstract.  Author URL.
Prince C, Sharp GC, Howe LD, Fraser A, Richmond RC (2022). The relationships between women’s reproductive factors: a Mendelian randomisation analysis. BMC Medicine, 20(1). Abstract.

2021

Alvergne A, Kountourides G, Argentieri A, Agyen L, Rogers N, Knight D, Sharp G, Maybin J, Olszewska Z (2021). COVID-19 vaccination and menstrual cycle changes: a United Kingdom (UK) retrospective case-control study.  Abstract.
Juvinao-Quintero DL, Marioni RE, Ochoa-Rosales C, Russ TC, Deary IJ, van Meurs JBJ, Voortman T, Hivert MF, Sharp GC, Relton CL, et al (2021). DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts. Clinical Epigenetics, 13(1). Abstract.
Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (2021). Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nat Genet, 53(9), 1311-1321. Abstract.  Author URL.
Prince C, Sharp GC, Howe LD, Fraser A, Richmond RC (2021). INVESTIGATING CAUSALITY BETWEEN ADIPOSITY AND WOMEN'S REPRODUCTIVE FACTORS: a MENDELIAN RANDOMIZATION ANALYSIS.  Author URL.
Richmond R, Rejon CS, Khouja J, Prince C, Board A, Sharp G, Suderman M, Relton C, Munafò M, Gage S, et al (2021). Investigating the DNA methylation profile of e-cigarette use.  Abstract.
Richmond RC, Sillero-Rejon C, Khouja JN, Prince C, Board A, Sharp G, Suderman M, Relton CL, Munafò M, Gage SH, et al (2021). Investigating the DNA methylation profile of e-cigarette use. Clin Epigenetics, 13(1). Abstract.  Author URL.
Schellhas L, Haan E, Easey KE, Wootton RE, Sallis HM, Sharp GC, Munafò MR, Zuccolo L (2021). Maternal and child genetic liability for smoking and caffeine consumption and child mental health: an intergenerational genetic risk score analysis in the ALSPAC cohort. Addiction, 116(11), 3153-3166. Abstract.
Sammallahti S, Cortes Hidalgo AP, Tuominen S, Malmberg A, Mulder RH, Brunst KJ, Alemany S, McBride NS, Yousefi P, Heiss JA, et al (2021). Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation. MOLECULAR PSYCHIATRY, 26(6), 1832-1845. Author URL.
Martin FZ, Easey KE, Howe LD, Lawlor DA, Fraser A, Relton CL, Sharp GC (2021). NOVEL RISK FACTORS FOR MENORRHAGIA AND DYSMENORRHEA IN ADOLESCENCE USING THE ALSPAC COHORT.  Author URL.
Sharp GC, Alfano R, Ghantous A, Urquiza J, Rifas-Shiman SL, Page CM, Jin J, Fernández-Barrés S, Santorelli G, Tindula G, et al (2021). Paternal body mass index and offspring DNA methylation: Findings from the PACE consortium. International Journal of Epidemiology, 50(4), 1297-1315. Abstract.
Berman S, Sharp G, Lewis S, Blakey R, Davies A, Humphries K, Wren Y, Sandy J, Stergiakouli E (2021). Prevalence and Factors Associated with Behavioural Problems in 5-year-old Children Born with Cleft Lip and/or Palate from the Cleft Collective.  Abstract.
Sharp G, Fraser A, Sawyer G, Kountourides G, Easey K, Ford G, Olszewska Z, Howe LD, Lawlor DA, Alvergne A, et al (2021). The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities.
Battram T, Yousefi P, Crawford G, Prince C, Babei MS, Sharp G, Hatcher C, Vega-Salas MJ, Khodabakhsh S, Whitehurst O, et al (2021). The EWAS Catalog: a database of epigenome-wide association studies.
Easey K, Sharp G (2021). The impact of paternal alcohol, tobacco, caffeine use and physical activity on offspring mental health: a systematic review and meta-analysis.  Abstract.
Easey KE, Sharp GC (2021). The impact of paternal alcohol, tobacco, caffeine use and physical activity on offspring mental health: a systematic review and meta-analysis. Reproductive Health, 18(1). Abstract.
Prince C, Sharp G, Howe L, Fraser A, Richmond R (2021). The relationships between women’s reproductive factors: a Mendelian randomization analysis.  Abstract.
Easey K, Sharp G (2021). USING DATA ON FATHERS/PARTNERS TO STUDY PRENATAL PARENTAL EXPOSURES AND CHILD HEALTH: CHALLENGES INTRODUCED BY MISSING DATA AND SELECTION BIAS.  Author URL.
Clarke SL, Mitchell RE, Sharp GC, Ramanan AV, Relton CL (2021). Vitamin D levels and risk of juvenile idiopathic arthritis: a Mendelian randomization study. Arthritis Care Res (Hoboken) Abstract.  Author URL.
Clarke SLN, Mageean KS, Carlton H, Simonini G, Sharp GC, Relton CL, Ramanan AV (2021). “Environmental risk factors associated with juvenile idiopathic arthritis associated uveitis: a systematic review of the literature”. Journal of Ophthalmic Inflammation and Infection, 11(1). Abstract.

2020

Neumann A, Walton E, Alemany S, Cecil C, Gonzalez JR, Jima DD, Lahti J, Tuominen ST, Barker ED, Binder E, et al (2020). Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis. TRANSLATIONAL PSYCHIATRY, 10(1). Author URL.
Dardani C, Howe LJ, Mukhopadhyay N, Stergiakouli E, Wren Y, Humphries K, Davies A, Ho K, Weinberg SM, Marazita ML, et al (2020). Cleft lip/palate and educational attainment: Cause, consequence or correlation? a Mendelian randomization study. International Journal of Epidemiology, 49(4), 1282-1293. Abstract.
Griffith GJ, Morris TT, Tudball MJ, Herbert A, Mancano G, Pike L, Sharp GC, Sterne J, Palmer TM, Davey Smith G, et al (2020). Collider bias undermines our understanding of COVID-19 disease risk and severity. Nature Communications, 11(1). Abstract.
Griffith G, Morris T, Tudball M, Herbert A, Mancano G, Pike L, Sharp G, Palmer T, Smith GD, Tilling K, et al (2020). Collider bias undermines our understanding of COVID-19 disease risk and severity.  Abstract.
Vehmeijer FOL, Küpers LK, Sharp GC, Salas LA, Lent S, Jima DD, Tindula G, Reese S, Qi C, Gruzieva O, et al (2020). DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies. Genome Medicine, 12(1). Abstract.
Merid SK, Novoloaca A, Sharp GC, Küpers LK, Kho AT, Roy R, Gao L, Annesi-Maesano I, Jain P, Plusquin M, et al (2020). Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age. Genome Medicine, 12(1). Abstract.
Schellhas L, Haan E, Easey K, Wootton R, Sallis H, Sharp G, Munafò M, Zuccolo L (2020). Maternal and child genetic liability for smoking and caffeine consumption and. child mental health: an intergenerational genetic risk score analysis in the. ALSPAC cohort.  Abstract.
Howe CG, Cox B, Fore R, Jungius J, Kvist T, Lent S, Miles HE, Salas LA, Rifas-Shiman S, Starling AP, et al (2020). Maternal gestational diabetes mellitus and newborn DNA Methylation: Findings from the pregnancy and childhood epigenetics consortium. Diabetes Care, 43(1), 98-105. Abstract.
Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, et al (2020). Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.
Sharp G, Alfano R, Ghantous A, Urquiza J, Rifas-Shiman S, Page C, Jin J, Fernández-Barrés S, Santorelli G, Tindula G, et al (2020). Paternal body mass index and offspring DNA methylation: findings from the PACE consortium.  Abstract.
Schellhas L, Lou M, Monasso G, Fernandez Barres S, Pesce G, Maesano IA, Page C, London S, Cecil C, Felix J, et al (2020). The epigenome as a biological pathway of the effects of prenatal exposure to tobacco, alcohol, and caffeine on childhood internalising problems in offspring: two large multi-cohort epigenome-wide association studies.  Author URL.
Sharp G, Schellhas L, Richardson S, Lawlor D (2020). Time to cut the cord: recognizing and addressing the imbalance of DOHaD research towards the study of maternal pregnancy exposures - CORRIGENDUM. J Dev Orig Health Dis, 11(1). Author URL.

2019

Richardson TG, Richmond RC, North TL, Hemani G, Davey Smith G, Sharp GC, Relton CL (2019). An integrative approach to detect epigenetic mechanisms that putatively mediate the influence of lifestyle exposures on disease susceptibility. International Journal of Epidemiology, 48(3), 887-898. Abstract.
Neumann A, Walton E, Alemany S, Cecil C, González JR, Jima DD, Lahti J, Tuominen ST, Barker ED, Binder E, et al (2019). Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis.
Juvinao-Quintero DL, Hivert M-F, Sharp GC, Relton CL, Elliott HR (2019). DNA Methylation and Type 2 Diabetes: the Use of Mendelian Randomization to Assess Causality. Curr Genet Med Rep, 7(4), 191-207. Abstract.  Author URL.
Staunstrup N, Viuff A-C, Sharp G, Pedersen L, Kyng K, Rai D, Relton C, Henriksen T (2019). EPIGENETIC DIFFERENCES IN CORD BLOOD OF NEWBORNS EXPOSED TO ANTIDEPRESSANT MEDICATION DURING PREGNANCY - a STUDY IN THE AARHUS BIRTH COHORT.  Author URL.
Elliott HR, Sharp GC, Relton CL, Lawlor DA (2019). Epigenetics and gestational diabetes: a review of epigenetic epidemiology studies and their use to explore epigenetic mediation and improve prediction. Diabetologia, 62(12), 2171-2178. Abstract.
Everson TM, Zhang H, Lockett GA, Kaushal A, Forthofer M, Ewart SL, Burrows K, Relton CL, Sharp GC, Henderson AJ, et al (2019). Epigenome-wide association study of asthma and wheeze characterizes loci within HK1. Allergy, Asthma and Clinical Immunology, 15(1), 1-12. Abstract.
Imboden M, Wielscher M, Rezwan FI, Amaral AFS, Schaffner E, Jeong A, Beckmeyer-Borowko A, Harris SE, Starr JM, Deary IJ, et al (2019). Epigenome-wide association study of lung function level and its change. European Respiratory Journal, 54(1). Abstract.
Reese SE, Xu CJ, den Dekker HT, Lee MK, Sikdar S, Ruiz-Arenas C, Merid SK, Rezwan FI, Page CM, Ullemar V, et al (2019). Epigenome-wide meta-analysis of DNA methylation and childhood asthma. Journal of Allergy and Clinical Immunology, 143(6), 2062-2074. Abstract.
Howe LJ, Richardson TG, Arathimos R, Alvizi L, Passos-Bueno MR, Stanier P, Nohr E, Ludwig KU, Mangold E, Knapp M, et al (2019). Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate. Epigenomics, 11(2), 133-145. Abstract.
Timms JA, Relton CL, Sharp GC, Rankin J, Strathdee G, McKay JA (2019). Exploring a potential mechanistic role of DNA methylation in the relationship between in utero and post-natal environmental exposures and risk of childhood acute lymphoblastic leukaemia. International Journal of Cancer, 145(11), 2933-2943. Abstract.
Kazmi N, Sharp GC, Reese SE, Vehmeijer FO, Lahti J, Page CM, Zhang W, Rifas-Shiman SL, Rezwan FI, Simpkin AJ, et al (2019). Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns: Findings from the Pregnancy and Childhood Epigenetics Consortium. Hypertension, 74(2), 375-383. Abstract.
Martin CL, Jima D, Sharp GC, McCullough LE, Park SS, Gowdy KM, Skaar D, Cowley M, Maguire RL, Fuemmeler B, et al (2019). Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study. Epigenetics, 14(4), 325-340. Abstract.
Küpers LK, Monnereau C, Sharp GC, Yousefi P, Salas LA, Ghantous A, Page CM, Reese SE, Wilcox AJ, Czamara D, et al (2019). Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. Nature Communications, 10(1). Abstract.
den Dekker HT, Burrows K, Felix JF, Salas LA, Nedeljkovic I, Yao J, Rifas-Shiman SL, Ruiz-Arenas C, Amin N, Bustamante M, et al (2019). Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course. European Respiratory Journal, 53(4). Abstract.
Xiong Z, Dankova G, Howe LJ, Lee MK, Hysi PG, de Jong MA, Zhu G, Adhikari K, Li D, Li Y, et al (2019). Novel genetic loci affecting facial shape variation in humans.
Sharp GC, Lawlor DA (2019). Paternal impact on the life course development of obesity and type 2 diabetes in the offspring. Diabetologia, 62(10), 1802-1810. Abstract.
Howe LJ, Sharp GC, Hemani G, Zuccolo L, Richmond S, Lewis SJ (2019). Prenatal alcohol exposure and facial morphology in a UK cohort. Drug and Alcohol Dependence, 197, 42-47. Abstract.
Sharp GC, Schellhas L, Richardson SS, Lawlor DA (2019). Time to cut the cord: Recognizing and addressing the imbalance of DOHaD research towards the study of maternal pregnancy exposures. Journal of Developmental Origins of Health and Disease, 10(5), 509-512.

2018

Ambatipudi S, Sharp GC, Clarke SLN, Plant D, Tobias JH, Evans DM, Barton A, Relton CL (2018). Assessing the role of DNA methylation-derived neutrophil-to-lymphocyte ratio in rheumatoid arthritis. Journal of Immunology Research, 2018 Abstract.
Arathimos R, Sharp GC, Granell R, Tilling K, Relton CL (2018). Associations of sex hormone-binding globulin and testosterone with genome-wide DNA methylation 06 Biological Sciences 0604 Genetics. BMC Genetics, 19(1). Abstract.
Dardani C, Howe LJ, Stergiakouli E, Wren Y, Humphries K, Davies A, Ho K, Mangold E, Ludwig KU, Relton CL, et al (2018). Cleft lip/palate and educational attainment: cause, consequence, or correlation? a Mendelian randomization study.
Felix JF, Joubert BR, Baccarelli AA, Sharp GC, Almqvist C, Annesi-Maesano I, Arshad H, Baiz N, Bakermans-Kranenburg MJ, Bakulski KM, et al (2018). Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium. International Journal of Epidemiology, 47(1), 22-23u.
Howe L, Richardson T, Arathimos R, Alvizi L, Passos-Bueno M-R, Stanier P, Nohr E, Ludwig K, Mangold E, Knapp M, et al (2018). DNA methylation mediates genetic liability to non-syndromic cleft lip/palate.  Abstract.
Sharp GC, Stergiakouli E, Sandy J, Relton C (2018). Epigenetics and Orofacial Clefts: a Brief Introduction. Cleft Palate-Craniofacial Journal, 55(6), 795-797.
Howe LJ, Lee MK, Sharp GC, Davey Smith G, St Pourcain B, Shaffer JR, Ludwig KU, Mangold E, Marazita ML, Feingold E, et al (2018). Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology. PLoS Genetics, 14(8). Abstract.
Howe L, Lee MK, Sharp G, Smith GD, Pourcain BS, Shaffer J, Marazita M, Feingold E, Zhurov A, Stergiakouli E, et al (2018). Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology.  Abstract.
Sharp GC, Lawlor DA, Richardson SS (2018). It's the mother!: How assumptions about the causal primacy of maternal effects influence research on the developmental origins of health and disease. Social Science and Medicine, 213, 20-27. Abstract.
Sharp GC, Arathimos R, Reese SE, Page CM, Felix J, Küpers LK, Rifas-Shiman SL, Liu C, Burrows K, Zhao S, et al (2018). Maternal alcohol consumption and offspring DNA methylation: Findings from six general population-based birth cohorts. Epigenomics, 10(1), 27-42. Abstract.
Viuff AC, Sharp GC, Rai D, Henriksen TB, Pedersen LH, Kyng KJ, Staunstrup NH, Cortes A, Neumann A, Felix JF, et al (2018). Maternal depression during pregnancy and cord blood DNA methylation: findings from the Avon Longitudinal Study of Parents and Children. Translational Psychiatry, 8(1). Abstract.
Xiong Z, Zhou H, Dankova G, Howe LJ, Lee MK, Hysi PG, de Jong MA, Zhu G, Adhikari K, Li D, et al (2018). Novel Genetic Loci Affecting Facial Shape Variation in Humans.
Howe L, Sharp G, Hemani G, Zuccolo L, Richmond S, Lewis S (2018). Prenatal alcohol exposure and facial morphology in a UK cohort.  Abstract.
Beckmeyer-Borowko A, Imboden M, Rezwan FI, Wielscher M, Amaral AFS, Jeong A, Schaffner E, Auvinen J, Sebert S, Karhunen V, et al (2018). SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts. Respiratory Research, 19(1). Abstract.
Richmond RC, Sharp GC, Herbert G, Atkinson C, Taylor C, Bhattacharya S, Campbell D, Hall M, Kazmi N, Gaunt T, et al (2018). The long-term impact of folic acid in pregnancy on offspring DNA methylation: Follow-up of the Aberdeen folic acid supplementation trial (AFAST). International Journal of Epidemiology, 47(3), 928-937. Abstract.

2017

Sharp GC, Ho K, Davies A, Stergiakouli E, Humphries K, McArdle W, Sandy J, Davey Smith G, Lewis SJ, Relton CL, et al (2017). Distinct DNA methylation profiles in subtypes of orofacial cleft. Clinical Epigenetics, 9(1). Abstract.
Sharp G, Ho K, Davies A, Stergiakouli E, Humphries K, McArdie W, Sandy J, Davey Smith G, Lewis S, Relton C, et al (2017). Distinct blood DNA methylation profiles in subtypes of orofacial cleft.  Abstract.
Sharp GC, Relton CL (2017). Epigenetics and noncommunicable diseases. Epigenomics, 9(6), 789-791.
Arathimos R, Suderman M, Sharp G, Burrows K, Granell R, Tilling K, Gaunt T, Henderson J, Ring S, Richmond R, et al (2017). Epigenome-wide association study of asthma and wheeze in childhood and adolescence.  Abstract.
Arathimos R, Suderman M, Sharp G, Burrows K, Granell R, Tilling K, Richmond R, Haycock P, Relton C (2017). Epigenome-wide association study of asthma and wheeze in childhood and adolescence.  Author URL.
Arathimos R, Suderman M, Sharp GC, Burrows K, Granell R, Tilling K, Gaunt TR, Henderson J, Ring S, Richmond RC, et al (2017). Epigenome-wide association study of asthma and wheeze in childhood and adolescence. Clinical Epigenetics, 9(1). Abstract.
Caramaschi D, Sharp GC, Nohr EA, Berryman K, Lewis SJ, Smith GD, Relton CL (2017). Exploring a causal role of DNA methylation in the relationship between maternal vitamin B-12 during pregnancy and child's IQ at age 8, cognitive performance and educational attainment: a two-step Mendelian randomization study. HUMAN MOLECULAR GENETICS, 26(15), 3001-3013. Author URL.
Sharp G, Salas L, Monnereau C, Allard C, Yousefi P, Everson T, Bohlin J, Xu Z, Huang R-C, Reese S, et al (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.  Abstract.
Sharp GC, Salas LA, Monnereau C, Allard C, Yousefi P, Everson TM, Bohlin J, Xu Z, Huang RC, Reese SE, et al (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics, 26(20), 4067-4085. Abstract.
Sharp G, Arathimos R, Reese S, Page C, Felix J, Küpers L, Rifas-Shiman S, Liu C, Burrows K, Zhao S, et al (2017). Maternal alcohol consumption during pregnancy and offspring epigenome-wide DNA methylation: findings from six general population-based birth cohorts.  Abstract.
Suderman M, Simpkin A, Sharp G, Gaunt T, Lyttleton O, McArdle W, Ring S, Davey Smith G, Relton C (2017). Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood.  Abstract.

2016

Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese SE, Markunas CA, Richmond RC, Xu CJ, et al (2016). DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. American Journal of Human Genetics, 98(4), 680-696. Abstract.
Richmond RC, Sharp GC, Ward ME, Fraser A, Lyttleton O, McArdle WL, Ring SM, Gaunt TR, Lawlor DA, Smith GD, et al (2016). DNA methylation and BMI: Investigating identified methylation sites at HIF3A in a causal framework. Diabetes, 65(5), 1231-1244. Abstract.
Simpkin AJ, Hemani G, Suderman M, Gaunt TR, Lyttleton O, Mcardle WL, Ring SM, Sharp GC, Tilling K, Horvath S, et al (2016). Prenatal and early life influences on epigenetic age in children: a study of mother-offspring pairs from two cohort studies. Human Molecular Genetics, 25(1), 191-201. Abstract.
Sharp GC, Hutchinson JL, Hibbert N, Freeman TC, Saunders PTK, Norman JE (2016). Transcription analysis of the myometrium of labouring and non-labouring women. PLoS ONE, 11(5). Abstract.

2015

Sharp GC, Lawlor DA, Richmond RC, Fraser A, Simpkin A, Suderman M, Shihab HA, Lyttleton O, McArdle W, Ring SM, et al (2015). Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: Findings from the Avon Longitudinal Study of Parents and Children. International Journal of Epidemiology, 44(4), 1288-1304. Abstract.

2014

Sharp GC, Stock SJ, Norman JE (2014). Fetal assessment methods for improving neonatal and maternal outcomes in preterm prelabour rupture of membranes. Cochrane Database of Systematic Reviews, 2014(10). Abstract.
Sharp GC, Saunders PTK, Greene SA, Morris AD, Norman JE (2014). Intergenerational transmission of postpartum hemorrhage risk: Analysis of 2 Scottish birth cohorts. American Journal of Obstetrics and Gynecology, 211(1), 51.e1-51.e7. Abstract.

2013

Sharp GC, Ma H, Saunders PTK, Norman JE (2013). A Computational Model of Lipopolysaccharide-Induced Nuclear Factor Kappa B Activation: a Key Signalling Pathway in Infection-Induced Preterm Labour. PLoS ONE, 8(7). Abstract.
Sharp G, Freeman T, Saunders P, Norman J (2013). A NOVEL NETWORK GRAPH APPROACH FOR THE ANALYSIS AND VISUALISATION OF EPIDEMIOLOGICAL DATA.  Author URL.
Sharp GC, Saunders PTK, Norman JE (2013). Computer models to study uterine activation at labour. Molecular Human Reproduction, 19(11), 711-717. Abstract.

2012

Sharp GC, Stock SJ, Norman JE (2012). Fetal assessment methods for improving neonatal and maternal outcomes in preterm prelabour rupture of membranes. In  (Ed) Cochrane Database of Systematic Reviews.

Gemma_Sharp Details from cache as at 2022-12-03 04:22:58

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External Engagement and Impact

I have an honorary position at the University of Bristol MRC Integrative Epidemiology Unit

Teaching

I teach undergraduate, postgraduate and continuing professional development courses relevant to my research interests and expertise in molecular epidemiology and reproductive health.

I enjoy designing courses, sessions and assessments that are ‘constructively alligned’, which helps student to meet the intended learning outcomes for the teaching. My sessions are interactive and use a range of media and activities. I particularly like using a ‘flipped classroom’ approach where students are given some digital material to read/watch/complete in their own time before coming to a live session to participate in interactive discussions and group tasks.

Modules

2022/23


Supervision / Group

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