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Dr Lee Hogarth

Dr Lee Hogarth

Associate Professor

 4613

 Washington Singer 224

 

Washington Singer Laboratories, University of Exeter, Perry Road, Prince of Wales Road, Exeter, EX4 4QG, UK

Overview

OFFICE HOURS TERM 1 2019-20:

Monday 4.30; Wednesday 3

My work over the past 20 years has focused on the abnormal learning processes underpinning the transition from recreational drug use to dependence, i.e. what makes some people more vulnerable to addiction. This work has been funded by the Wellcome Trust, BBSRC, ESRC and MRC and Alcohol Research UK. I have developed a range of novel human laboratory procedures inspired by animal behavioral neuroscience to study dependence liability. My PhD and early post-doctoral work was inspired by the claim of incentive salience theory that drug related cues command selective attention which controls automatic drug-seeking. I developed a novel conditioning procedure to measure acquired attentional bias for drug paired cues with eye tracking(1). However, the attentional bias established by drug conditioning was not reliably associated with level of dependence, and could be abolished without affecting the capacity of the stimulus control of drug-seeking behavior(2, 3). I concluded that incentive salience for drug cues does not underpin dependence vulnerability and is not a viable target for treatment. For this reason, I moved on to study whether dependence is driven by drug cues eliciting greater drug-seeking behavior(4), and was the first person to develop a human Pavlovian to instrumental transfer procedure with drug rewards (a mainstay of animal behavioral neuroscience) for this purpose(5). However, once again, the ability of external drug cues to promote drug-seeking behavior was not associated with dependence severity(6-9), and so this process could not underpin vulnerability(10-14). I then returned to test the preferred hypothesis of my one time PhD supervisor, Anthony Dickinson (FRS) – that drug dependence is driven by excessive habit learning, that is, the tendency to repeat well practiced drug-seeking behavior without forethought for the consequences. To study this process, I was the first person to develop a novel outcome-devaluation procedure (another mainstay of animal behavioral neuroscience) for humans with drug reinforcers(6, 7). With this method, I demonstrated that human drug-seeking was habitual under conditions of cognitive load(15-18). However, such habit learning was not more pronounced in individuals with greater dependence and so could not underpin vulnerability(6, 7, 11). Despite these wrong turns, my recent work has revealed what learning processes underpin dependence vulnerability. There are, it seems, two independent vulnerabilities. Behavioral economists have long espoused the first vulnerability; that some individuals experience drugs as more reinforcing and so choose drugs preferentially over other natural rewards, accounting for individual differences in dependence level. My work with the outcome-devaluation procedure has supported this view, demonstrating that preferential drug choice in more dependent individuals is goal-directed, that is, driven by an expectation of greater reward value of the drug, and is not automatic or habitual as commonly claimed (6, 7, 9, 19-21). The second (additive) vulnerability is that some individuals experience greater negative emotions, psychiatric symptoms, withdrawal related states, cognitive impairments or physical ailments which can be acutely mitigated by drug use, endowing these negative states with capacity to raise the expected rewards value of the drug, thus motivating goal-directed drug-seeking(22-26). My recent work has demonstrated experimentally that negative states act as powerful motivators of goal-directed tobacco-seeking(22, 23) and that individuals with depression are more vulnerable to such negative triggers for tobacco-seeking(26, 27). This novel affective incentive learning account of dependence vulnerability has also been explicated in a high profile review article(25). My current work focuses on hypersensitivity to negative triggers for drug use in groups with comorbid psychiatric illness, to inform understanding of mechanisms, as well as treatment and prevention strategies for vulnerable drug user groups.

1.         Hogarth L., Dickinson A., Hutton S. B., Elbers N., Duka T. Drug expectancy is necessary for stimulus control of human attention, instrumental drug-seeking behaviour and subjective pleasure, Psychopharmacology 2006: 185: 495-504.

2.         Hogarth L., Dickinson A., Janowski M., Nikitina A., Duka T. The role of attentional bias in mediating human drug seeking behaviour, Psychopharmacology 2008: 201: 29–41.

3.         Hogarth L., Dickinson A., Duka T. Detection versus sustained attention to drug cues have dissociable roles in mediating drug seeking behaviour, Exp Clin Psychopharmacol 2009: 17: 21-30.

4.         Hogarth L., Duka T. Human nicotine conditioning requires explicit contingency knowledge: is addictive behaviour cognitively mediated?, Psychopharmacology 2006: 184: 553-566.

5.         Hogarth L., Dickinson A., Wright A., Kouvaraki M., Duka T. The role of drug expectancy in the control of human drug seeking, J Exp Psychol Anim Behav Process 2007: 33: 484-496.

6.         Hogarth L., Chase H. W. Parallel goal-directed and habitual control of human drug-seeking: Implications for dependence vulnerability, J Exp Psychol: Anim Behav Processes 2011: 37: 261-276.

7.         Hogarth L. Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: Evidence for independent additive controllers, J Exp Psychol: Anim Behav Processes 2012: 38: 266-278.

8.         Martinovic J., Jones A., Christiansen P., Rose A. K., Hogarth L., Field M. Electrophysiological responses to alcohol cues are not associated with Pavlovian-to-instrumental transfer in social drinkers, PLoS One 2014: 9: e94605.

9.         Hogarth L., Chase H. W. Evaluating psychological markers for human nicotine dependence: Tobacco choice, extinction, and Pavlovian-to-instrumental transfer, Exp Clin Psychopharmacol 2012: 20: 213-224.

10.       Hogarth L., Troisi J. R. I. A hierarchical instrumental decision theory of nicotine dependence. In: Balfour D. J. K. & Munafò M. R., editors. The Neurobiology and Genetics of Nicotine and Tobacco: Springer International Publishing; 2015, p. 165-191.

11.       Hogarth L. Controlled and automatic learning processes in addiction. In: Pickard H. & Ahmed S., editors. The Routledge Handbook of Philosophy and Science of Addiction, London and New York: Routledge; In Press.

12.       Hogarth L., Balleine B. W., Corbit L. H., Killcross S. Associative learning mechanisms underpinning the transition from recreational drug use to addiction, Ann N Y Acad Sci 2013: 1282: 12-24.

13.       Hitsman B., Hogarth L., Tseng L.-J., Teige J. C., Shadel W. G., Dibenedetti D. B. et al. Dissociable effect of acute varenicline on tonic versus cue-provoked craving in non-treatment-motivated heavy smokers, Drug Alcohol Depend 2013: 130: 135-141.

14.       Hardy L., Mitchell C., Seabrooke T., Hogarth L. Drug cue reactivity involves hierarchical instrumental learning: evidence from a biconditional Pavlovian to instrumental transfer task, Psychopharmacology 2017: 234: 1977-1984.

15.       Hogarth L., Attwood A. S., Bate H. A., Munafò M. R. Acute alcohol impairs human goal-directed action, Biological Psychology 2012: 90: 154-160.

16.       Hogarth L., Chase H. W., Baess K. Impaired goal-directed behavioural control in human impulsivity, Q J Exp Psychol 2012: 65: 305-316.

17.       Hogarth L., Field M., Rose A. K. Phasic transition from goal-directed to habitual control over drug-seeking produced by conflicting reinforcer expectancy, Addict Biol 2013: 18: 88–97.

18.       Pritchard T., Weidemann G., Hogarth L. Negative emotional appraisal selectively disrupts retrieval of expected outcome values required for goal-directed instrumental choice, Cognition and Emotion 2017: in press.

19.       Chase H. W., Mackillop J., Hogarth L. Isolating behavioural economic indices of demand in relation to nicotine dependence, Psychopharmacology 2013: 226: 371-380.

20.       Rose A. K., Brown K., Field M., Hogarth L. The contributions of value-based decision-making and attentional bias to alcohol-seeking following devaluation, Addiction 2013: 108: 1241-1249.

21.       Panlilio L. V., Hogarth L., Shoaib M. Concurrent access to nicotine and sucrose in rats, Psychopharmacology 2015: 232: 1451-1460.

22.       Hogarth L., He Z., Chase H. W., Wills A. J., Troisi J., Ii, Leventhal A. M. et al. Negative mood reverses devaluation of goal-directed drug-seeking favouring an incentive learning account of drug dependence, Psychopharmacology 2015: 232: 3235-3247.

23.       Hogarth L., Hardy L. Depressive statements prime goal-directed alcohol-seeking in individuals who report drinking to cope with negative affect, Psychopharmacology in press.

24.       Hardy L., Hogarth L. A novel concurrent pictorial choice model of mood-induced relapse in hazardous drinkers, Exp Clin Psychopharmacol in press.

25.       Mathew A. R., Hogarth L., Leventhal A. M., Cook J. W., Hitsman B. Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model, Addiction 2017: 112: 401-412.

26.       Hogarth L., Mathew A. R., Hitsman B. Current major depression is associated with greater sensitivity to the motivational effect of both negative mood induction and abstinence on tobacco-seeking behavior, Drug Alcohol Depend 2017: 176: 1-6.

27.       Hogarth L., Hardy L., Mathew A. R., Hitsman B. Negative mood-induced alcohol-seeking is greater in young adults who report depression symptoms, drinking to cope, and subjective reactivity, Exp Clin Psychopharmacol: in press.

Qualifications

BSc Hons 1st, Sussex,
PhD, Cambridge

Career

I received my PhD from Cambridge University in 2000 for research on conditioning processes in human addiction supervised by Prof Anthony Dickinson. I then obtained two grants (Wellcome, BBSRC) supporting 7 years of postdoctoral research on attentional learning at Sussex University with Prof Theodora Duka. I obtained a lectureship at Nottingham University in 2007 and shortly after was awarded an MRC young investigators award for 3 years of research on individual differences in associative learning underlying addiction vulnerability. I took up a Senior Lectureship at the University of New South Wales (UNSW), Australia, in 2012, under the academic lead of Prof Simon Killcross. Finally, I returned home in 2013 to take up an Associate Professorship at Exeter University under the academic lead of Prof. Ian McLaren.

Links

Research group links

Research

Research interests

Contributions to Science 

1. Incentive salience theory of addiction in humans

My PhD and early Postdoctoral research tested Robinson and Berridge’s (1993) incentive salience theory of addiction in humans. This account predicts that (a) drug addicts should have their attention captured by drug cues, (b) attentional capture by drug cues should play a causal role in driving drug-seeking behavior, and therefore (c) abolishing the attentional bias should reduce cue-elicited drug-seeking. My first publication was one of the earliest demonstrations that drug cues do in fact capture addicts’ attention, using a reaction time measure of attention(A) and is in the top 10% for citations relative to comparable articles based on Scopus data. My subsequent work demonstrated that this attentional bias could be conditioned to arbitrary stimuli and measured more sensitively by eye tracking(B). However, I later discovered that abolishing the attentional bias did not reduce the ability of drug cues to elicit drug-seeking behavior, suggesting that abolishing the attentional bias will not provide a viable therapeutic intervention for addiction(C,D). This latter paper is in the top 30% for citations despite contradicting a core tenet within addiction theory. My prediction from this pre-clinical work, that attentional bias retraining would not yield therapeutic benefits, has been confirmed by clinical trials.

A. Hogarth LC, Mogg K, Bradley BP, Duka T, Dickinson A. Attentional orienting towards smoking-related stimuli. Behav Pharmacol. 2003 Mar;14(2):153-60. PMID: 12658076.

B. Hogarth L, Dickinson A, Hutton SB, Elbers N, Duka T. Drug expectancy is necessary for stimulus control of human attention, instrumental drug-seeking behaviour and subjective pleasure. Psychopharmacology (Berl). 2006 May;185(4):495-504. PMID: 16547713.

C. Hogarth L, Dickinson A, Janowski M, Nikitina A, Duka T. The role of attentional bias in mediating human drug-seeking behaviour. Psychopharmacology (Berl). 2008 Nov;201(1):29-41. PMID: 18679657.

D. Hogarth L, Dickinson A, Duka T. Detection versus sustained attention to drug cues have dissociable roles in mediating drug seeking behavior. Exp Clin Psychopharmacol. 2009 Feb;17(1):21-30. PMID: 19186931.

 

2. Drug cue-reactivity

Having discovered that attentional bias for drug cues is not a viable target for therapy, I switched to studying the decision mechanisms underpinning drug cue-reactivity. My first aim was to test whether cue elicited drug-seeking is automatic as predicted by implicit accounts, or driven by an expectation of the drug as predicted by decision making accounts. To test these predictions, I was the first person to develop an outcome-specific Pavlovian to instrumental transfer (PIT) procedure for humans with drug reinforcers (a method only previously used in animal behavioural neuroscience). My human procedure demonstrated that a drug stimulus could transfer selective control over a separately trained drug-seeking response, but not over a response trained with a different reinforcer(A) (top 6% cited). To produce this effect, the drug stimulus must have retrieved an expectation of the drug which selectively primed drug-seeking. This effect cannot be explained by automatic, habitual or implicit accounts of drug cue-reactivity.

Paradoxically, I later found that the selective control by a tobacco stimulus over a tobacco-seeking response was not attenuated by nicotine replacement therapy (NRT)(B) (top 7% cited). Furthermore, Dr. Hitsman and I extended this result, finding that that cue-elicited tobacco craving was also not attenuated by varenicline(C) (top 25% cited). The implication of these findings is that drug cues elicit drug-seeking by retrieving an expectation that the drug-seeking response has a higher probability of being reinforced, irrespective of whether the drug outcome currently has low value. I subsequently, confirmed this view experimentally and outlined the implications for cue-retraining therapies(D) (top10% cited).

The crucial observation across all of these studies, however, was that the capacity of drug cues to prime drug-seeking in the PIT procedure was not associated with individual differences in level of dependence(A,B,D). Thus, drug cue-reactivity is not the principal mechanism underpinning risk of dependence, so I turned my research program away from this outcome measure.

A. Hogarth L, Dickinson A, Wright A, Kouvaraki M, Duka T. The role of drug expectancy in the control of human drug seeking. J Exp Psychol Anim Behav Process. 2007 Oct;33(4):484-96. PMID: 17924795.

B. Hogarth L. Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: evidence for independent additive controllers. J  Exp Psychol Anim Behav Process. 2012 Jul;38(3):266-78. PMID: 22823420.

C. Hitsman B, Hogarth L, Tseng LJ, Teige JC, Shadel WG, DiBenedetti DB, Danto S, Lee TC, Price LH, Niaura R. Dissociable effect of acute varenicline on tonic versus cue-provoked craving in non-treatment-motivated heavy smokers. Drug Alcohol Depend. 2013 Jun 1;130(1-3):135-41. PubMed PMID: 23201174.

D. Hogarth L, Retzler C, Munafò MR, Tran DM, Troisi JR 2nd, Rose AK, Jones A, Field M. Extinction of cue-evoked drug-seeking relies on degrading hierarchical instrumental expectancies. Behav Res Ther. 2014 Aug;59:61-70. PMID: 25011113.

 

3. Habit learning theory of addiction in humans

My PhD supervisor, Anthony Dickinson, had previously developed the habit learning theory of addiction in animals, and this account has since become a popular account of addiction in humans. On this view, drug-seeking is at first goal-directed (driven by the expected value of the drug), and progressively becomes habitual through practice (automatically elicited by drug related contexts without forethought for the consequences). Individual differences in vulnerability to dependence is driven by a propensity for drug-seeking to shift from being goal-directed to habitual, making the behaviour less amenable to cognitive regulation. To test this prediction, I was the first person to develop an outcome devaluation protocol for humans with drug reinforcers based on the animal model (A,B) (top 5% and 6% cited respectively). This work revealed that although drug-seeking could be rendered habitual under conditions of acute alcohol intoxication(C) (top 9% cited) or cognitive load (D) (top 20% cited), under normal conditions, drug-seeking is goal-directed rather than habitual. Furthermore, more dependent individuals were not more susceptible to drug-seeking becoming habitual(A,B,C,D). Instead, they engage in higher frequency of goal-directed drug-seeking, suggesting dependence is driven by greater expected reward value of the drug (consistent with behavioural-economic accounts). I have concluded from these findings that the evidence for habitual drug-seeking in animals is a product of the invariant nature of their laboratory experience, and that habit theory does not account for addiction in human.

A. Hogarth L, Chase HW. Parallel goal-directed and habitual control of human drug-seeking: implications for dependence vulnerability. J Exp Psychol Anim Behav Process. 2011 Jul;37(3):261-76. PMID: 21500933.

B. Hogarth L. Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: evidence for independent additive controllers. J Exp Psychol Anim Behav Process. 2012 Jul;38(3):266-78. PMID: 22823420.

C. Hogarth L, Attwood AS, Bate HA, Munafò MR. Acute alcohol impairs human goal-directed action. Biol Psychol. 2012 May;90(2):154-60. PMID: 22406757.

D. Hogarth L, Field M, Rose AK. Phasic transition from goal-directed to habitual control over drug-seeking produced by conflicting reinforcer expectancy. Addict Biol. 2013 Jan;18(1):88-97. PMID: 23167442.

 

4. Negative reinforcement theory of drug dependence

My previous work had suggested that individual differences in sub-clinical dependence is driven by the greater expected reward value of the drug driving higher rates of goal-directed drug-seeking. The suspicion, however, was that a second process contributed to clinical addiction. According to negative reinforcement theories, negative states such as depression, anxiety, withdrawal, cognitive deficits etc., powerfully motivate drug-seeking to acutely mitigate those states. Dr. Hitsman and myself hypothesized that individual sensitivity to such negative triggers motivating goal-directed drug-seeking would be the crucial process underpinning clinical dependence. In testing this hypothesis, we adapted the outcome-devaluation procedure to demonstrate that acute negative mood can powerfully motivate drug-seeking behavior, fully countermanding the capacity of drug satiety to reduce goal-directed drug-seeking(A). We then demonstrated that smokers with current major depression are more sensitive to negative mood and withdrawal induced motivation of tobacco-seeking(B) and young adult drinkers with depression symptoms are more sensitive to negative mood-induced increases in alcohol-seeking(C). We have also synthesized this goal-directed account of drug dependence vulnerability in a high profile review article(D). Overall, we argue that individual differences in sub-clinical dependence are driven by the greater expected reward value of the drug driving higher rates of goal-directed drug-seeking. This process is amplified by negative motivational states in groups with comorbid psychiatric symptoms, which powerfully promote goal-directed drug-seeking producing the pathological character of clinical addiction. Our current work focuses on hypersensitivity to negative triggers for drug use in groups with comorbid psychiatric illness, to inform understanding of mechanisms, as well as treatment and prevention strategies for vulnerable drug user groups.

A. Hogarth, L., He, Z., Chase, H. W., Wills, A. J., Troisi, J., II, Leventhal, A. M., (…), Hitsman, B. (2015). Negative mood reverses devaluation of goal-directed drug-seeking favouring an incentive learning account of drug dependence. Psychopharmacology, 232(17), 3235-3247.  PMID: 26041336.

B. Hogarth, L., Mathew, A. R., & Hitsman, B. (2017). Current major depression is associated with greater sensitivity to the motivational effect of both negative mood induction and abstinence on tobacco-seeking behavior. Drug and Alcohol Dependence, 176, 1-6. PMID: 28460322

C. Hogarth, L., Hardy, L., Mathew, A. R., & Hitsman, B. (in press) Negative mood-induced alcohol-seeking is greater in young adults who report depression symptoms, drinking to cope, and subjective reactivity. Experimental and Clinical Psychopharmacology.

D. Mathew, A. R., Hogarth, L., Leventhal, A. M., Cook, J. W., & Hitsman, B. (2017). Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model. Addiction, 112(3), 401-412. PMID: 27628300.

 

Research projects

Exeter Translational Addiction Partnership (ETAP)
Exeter Translational Addiction Partnership seeks to bridge between research on substance dependence at University of Exeter and the therapeutic services delivered by the charity EDP Drug & Alcohol Services to the community and prison population.

Grants/Funding:

2017 Alcohol Research Council grant: The therapeutic effect of Brief Adaptive Coping Training (BACT) on relapse to alcohol provoked by negative emotional experience.

2013 Australian Research Council Grant: Advancing the science of willpower - investigating the mechanisms and processes of self-control. With Prof. Martin Hagger, Curtin University, Western Australia.

2012 ESRC Project Grant: Alcohol seeking and consumption - the role of reward valuation and attentional bias. With Dr. Abigail Rose, University of Liverpool.

2011 MRC Project Grant: Human drug dependence - cognitive predisposition and neural mechanisms.

2011 Alcohol Education and Research council grant: Neurophysiological correlates of Pavlovian to instrumental transfer in heavy drinkers. With Dr. Matt Field, University of Liverpool.

2007 BBSRC Project Grant: Attentional mediation of conditioned appetitive behaviour in humans. With Prof. Theodora Duka, University of Sussex, and Prof. Anthony Dickinson, University of Cambridge.

Research networks

Dr. Brian Hitsman at Northwestern University and Dr. Robert Schnoll at University of Pennsylvania: Clinical evaluation of smoking cessation pharmacotherapy.

Prof. Marcus Munafò and Dr. Angela Attwood at Bristol University: Pre-clinical pharmacological and behavioural approaches to attenuating human drug-seeking.

Prof. Matt Field and Dr. Abigail Rose at Liverpool University: Behavioural approaches to understand and treat alcohol dependence.

Prof. Martin Hagger at Curtin University, Western Australia: Protective effects of glucose against relapse induced by loss of cognitive control.

Dr. Mohammed Shoaib at Newcastle University: Animal models of drug dependence vulnerability.

Dr. Lynne Dawkins at University of East London: Transfer of dependence to e-cigarettes.

Publications

Key publications | Publications by category | Publications by year

Key publications


Hogarth L, Mathew AR, Hitsman B (In Press). Current major depression is associated with greater sensitivity to the motivational effect of both negative mood induction and abstinence on tobacco-seeking behavior. Drug and Alcohol Dependence Full text.
Hogarth L, Lam-Cassettari C, Pacitti H, Currah T, Mahlberg J, Hartley L, Moustafa A (In Press). Intact goal-directed control in treatment-seeking drug users indexed by outcome-devaluation and Pavlovian to instrumental transfer: Critique of habit theory. European Journal of Neuroscience Full text.
Mathew AR, Hogarth L, Leventhal AM, Cook JW, Hitsman B (2017). Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model. Addiction, 112(3), 401-412. Abstract.  Author URL.  Full text.
Hogarth L, He Z, Chase HW, Wills AJ, Troisi J, Leventhal AM, Mathew AR, Hitsman B (2015). Negative mood reverses devaluation of goal-directed drug-seeking favouring an incentive learning account of drug dependence. Psychopharmacology (Berl), 232(17), 3235-3247. Abstract.  Author URL.  Full text.
Hogarth L, Maynard OM, Munafò MR (2015). Plain cigarette packs do not exert Pavlovian to instrumental transfer of control over tobacco-seeking. Addiction, 110(1), 174-182. Abstract.  Author URL.  Full text.
Hogarth L, Retzler C, Munafò MR, Tran DMD, Troisi JR, Rose AK, Jones A, Field M (2014). Extinction of cue-evoked drug-seeking relies on degrading hierarchical instrumental expectancies. Behav Res Ther, 59, 61-70. Abstract.  Author URL.  Full text.

Publications by category


Books

Hogarth L (2018). A Critical Review of Habit Theory of Drug Dependence.
Hogarth L (2018). Controlled and automatic learning processes in addiction.
Haselgrove M, Hogarth L (2011). Clinical Applications of Learning Theory., Psychology Press. Abstract.

Journal articles

Hardy L, Hogarth L (In Press). A novel concurrent pictorial choice model of mood-induced relapse in hazardous drinkers. Experimental and clinical psychopharmacology Full text.
Rose AK, Brown K, MacKillop J, Field M, Hogarth L (In Press). Alcohol devaluation has dissociable effects on distinct components of alcohol behaviour. Psychopharmacology Full text.
Hogarth L, Mathew AR, Hitsman B (In Press). Current major depression is associated with greater sensitivity to the motivational effect of both negative mood induction and abstinence on tobacco-seeking behavior. Drug and Alcohol Dependence Full text.
Hogarth L, Seabrooke T, Edmunds C, Mitchell C (In Press). Goal-directed control in Pavlovian-instrumental transfer. Journal of Experimental Psychology: Animal Learning and Cognition Full text.
Hogarth L, Lam-Cassettari C, Pacitti H, Currah T, Mahlberg J, Hartley L, Moustafa A (In Press). Intact goal-directed control in treatment-seeking drug users indexed by outcome-devaluation and Pavlovian to instrumental transfer: Critique of habit theory. European Journal of Neuroscience Full text.
Hogarth L, Shuai R, Bakou AE, Hardy L (In Press). Ultra-brief breath counting (mindfulness) training promotes recovery from stress-induced alcohol-seeking in student drinkers. Addictive Behaviors Full text.
Seabrooke T, Wills AJ, Hogarth L, Mitchell CJ (2019). Automaticity and cognitive control: Effects of cognitive load on cue-controlled reward choice. Quarterly journal of experimental psychology (2006), 72(6), 1507-1521. Abstract.  Full text.
Hogarth L (2019). Cue-elicited craving and human Pavlovian-to-instrumental transfer. Addiction Research & Theory
Hogarth L, Hardy L, Bakou A, Mahlberg J, Weidemann G, Cashel S, Moustafa AA (2019). Negative Mood Induction Increases Choice of Heroin Versus Food Pictures in Opiate-Dependent Individuals: Correlation with Self-Medication Coping Motives and Subjective Reactivity. FRONTIERS IN PSYCHIATRY, 10 Author URL.  Full text.
Hogarth L (2019). Relationship between childhood abuse and substance misuse problems is mediated by substance use coping motives, in school attending South African adolescents. Drug and Alcohol Dependence Full text.
Hogarth L (2018). A concurrent pictorial drug choice task marks multiple risk factors in treatment-engaged smokers and drinkers. Behavioural Pharmacology Full text.
Hogarth L (2018). Alcohol use disorder symptoms are associated with greater relative value ascribed to alcohol, but not greater discounting of costs imposed on alcohol. Psychopharmacology Full text.
Miele A, Thompson M, Jao NC, Kalhan R, Leone F, Hogarth L, Hitsman B, Schnoll R (2018). Cancer Patients Enrolled in a Smoking Cessation Clinical Trial: Characteristics and Correlates of Smoking Rate and Nicotine Dependence. Journal of addiction Full text.
Hardy L, Josephy K, McAndrew A, Hawksley P, Hartley L, Hogarth L (2018). Evaluation of the Peninsula Alcohol and Violence Programme (PAVP) with violent offenders. Addiction Research & Theory, 0, 1-8. Abstract.  Full text.
Pritchard TL, Weidemann G, Hogarth L (2018). Negative emotional appraisal selectively disrupts retrieval of expected outcome values required for goal-directed instrumental choice. Cogn Emot, 32(4), 843-851. Abstract.  Author URL.  Full text.
Hogarth L (2018). Negative mood-induced alcohol-seeking is greater in young adults who report depression symptoms, drinking to cope, and subjective reactivity. Experimental and Clinical Psychopharmacology Full text.
Mathew AR, Hogarth L, Leventhal AM, Cook JW, Hitsman B (2017). Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model. Addiction, 112(3), 401-412. Abstract.  Author URL.  Full text.
Hogarth L, Hardy L (2017). Depressive statements prime goal-directed alcohol-seeking in individuals who report drinking to cope with negative affect. Psychopharmacology, 235, 269-279. Full text.
Hardy L, Mitchell C, Seabrooke T, Hogarth L (2017). Drug cue reactivity involves hierarchical instrumental learning: evidence from a biconditional Pavlovian to instrumental transfer task. Psychopharmacology (Berl), 234(13), 1977-1984. Abstract.  Author URL.  Full text.
Seabrooke T, Le Pelley ME, Hogarth L, Mitchell CJ (2017). Evidence of a goal-directed process in human Pavlovian-instrumental transfer. J Exp Psychol Anim Learn Cogn, 43(4), 377-387. Abstract.  Author URL.  Full text.
Myers CE, Rego J, Haber P, Morley K, Beck KD, Hogarth L, Moustafa AA (2017). Learning and generalization from reward and punishment in opioid addiction. Behav Brain Res, 317, 122-131. Abstract.  Author URL.  Full text.
Mahlberg J, Haber P, Morley K, Weidemann G, Hogarth L, Beck KD, Myers CE, Moustafa AA (2017). Reward and punishment-based compound cue learning and generalization in opiate dependency. Exp Brain Res, 235(10), 3153-3162. Abstract.  Author URL.  Full text.
Mathew AR, Hogarth L, Leventhal AM, Cook JW, Hitsman B (2016). Cigarette smoking and depression comorbidity: systematic review & proposed theoretical model. Addiction
Sheynin J, Moustafa AA, Beck KD, Servatius RJ, Casbolt PA, Haber P, Elsayed M, Hogarth L, Myers CE (2016). Exaggerated acquisition and resistance to extinction of avoidance behavior in treated heroin-dependent men. J Clin Psychiatry, 77(3), 386-394. Abstract.  Author URL.
Myers CE, Sheynin J, Balsdon T, Luzardo A, Beck KD, Hogarth L, Haber P, Moustafa AA (2016). Probabilistic reward- and punishment-based learning in opioid addiction: Experimental and computational data. Behav Brain Res, 296, 240-248. Abstract.  Author URL.
Seabrooke T, Hogarth L, Mitchell CJ (2016). The propositional basis of cue-controlled reward seeking. Q J Exp Psychol (Hove), 69(12), 2452-2470. Abstract.  Author URL.  Full text.
Field M, Werthmann J, Franken I, Hofmann W, Hogarth L, Roefs A (2016). The role of attentional bias in obesity and addiction. Health Psychol, 35(8), 767-780. Abstract.  Author URL.
Panlilio LV, Hogarth L, Shoaib M (2015). Concurrent access to nicotine and sucrose in rats. Psychopharmacology (Berl), 232(8), 1451-1460. Abstract.  Author URL.  Full text.
Maynard OM, Leonards U, Attwood AS, Bauld L, Hogarth L, Munafò MR (2015). Effects of first exposure to plain cigarette packaging on smoking behaviour and attitudes: a randomised controlled study. BMC Public Health, 15(1). Abstract.  Full text.
Hogarth L, He Z, Chase HW, Wills AJ, Troisi J, Leventhal AM, Mathew AR, Hitsman B (2015). Negative mood reverses devaluation of goal-directed drug-seeking favouring an incentive learning account of drug dependence. Psychopharmacology (Berl), 232(17), 3235-3247. Abstract.  Author URL.  Full text.
Hogarth L, Maynard OM, Munafò MR (2015). Plain cigarette packs do not exert Pavlovian to instrumental transfer of control over tobacco-seeking. Addiction, 110(1), 174-182. Abstract.  Author URL.  Full text.
Martinovic J, Jones A, Christiansen P, Rose AK, Hogarth L, Field M (2014). Electrophysiological responses to alcohol cues are not associated with Pavlovian-to-instrumental transfer in social drinkers. PLoS One, 9(4). Abstract.  Author URL.  Full text.
Hogarth L, Retzler C, Munafò MR, Tran DMD, Troisi JR, Rose AK, Jones A, Field M (2014). Extinction of cue-evoked drug-seeking relies on degrading hierarchical instrumental expectancies. Behav Res Ther, 59, 61-70. Abstract.  Author URL.  Full text.
Maynard OM, Leonards U, Attwood AS, Bauld L, Hogarth L, Munafò MR (2014). Plain packaging of cigarettes and smoking behavior: study protocol for a randomized controlled study. Trials, 15 Abstract.  Author URL.  Full text.
Hogarth L, Balleine BW, Corbit LH, Killcross S (2013). Associative learning mechanisms underpinning the transition from recreational drug use to addiction. Ann N Y Acad Sci, 1282, 12-24. Abstract.  Author URL.  Full text.
Hogarth L, Stillwell DJ, Tunney RJ (2013). BIS impulsivity and acute nicotine exposure are associated with discounting global consequences in the Harvard game. Hum Psychopharmacol, 28(1), 72-79. Abstract.  Author URL.
Hitsman B, Hogarth L, Tseng L-J, Teige JC, Shadel WG, DiBenedetti DB, Danto S, Lee TC, Price LH, Niaura R, et al (2013). Dissociable effect of acute varenicline on tonic versus cue-provoked craving in non-treatment-motivated heavy smokers. Drug and Alcohol Dependence, 130, 135-141.
Chase HW, Mackillop J, Hogarth L (2013). Isolating behavioural economic indices of demand in relation to nicotine dependence. Psychopharmacology (Berl), 226(2), 371-380. Abstract.  Author URL.
Hogarth L, Field M, Rose AK (2013). Phasic transition from goal-directed to habitual control over drug-seeking produced by conflicting reinforcer expectancy. Addiction Biology, 18, 88-97. Full text.
Rose AK, Brown K, Field M, Hogarth L (2013). The contributions of value-based decision-making and attentional bias to alcohol-seeking following devaluation. Addiction, 108(7), 1241-1249. Abstract.  Author URL.
Hogarth L, Attwood AS, Bate HA, Munafò MR (2012). Acute alcohol impairs human goal-directed action. Biol Psychol, 90(2), 154-160. Abstract.  Author URL.
Hogarth L, Chase HW (2012). Evaluating psychological markers for human nicotine dependence: tobacco choice, extinction, and Pavlovian-to-instrumental transfer. Exp Clin Psychopharmacol, 20(3), 213-224. Abstract.  Author URL.
Hogarth L (2012). Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: evidence for independent additive controllers. J Exp Psychol Anim Behav Process, 38(3), 266-278. Abstract.  Author URL.  Full text.
Hogarth L, Chase HW, Baess K (2012). Impaired goal-directed behavioural control in human impulsivity. Q J Exp Psychol (Hove), 65(2), 305-316. Abstract.  Author URL.  Full text.
Jones A, Hogarth L, Christiansen P, Rose AK, Martinovic J, Field M (2012). Reward expectancy promotes generalized increases in attentional bias for rewarding stimuli. Q J Exp Psychol (Hove), 65(12), 2333-2342. Abstract.  Author URL.
Field M, Hogarth L, Bleasdale D, Wright P, Fernie G, Christiansen P (2011). Alcohol expectancy moderates attentional bias for alcohol cues in light drinkers. Addiction, 106(6), 1097-1103. Abstract.  Author URL.
Craig M, Pennacchia A, Wright NR, Chase HW, Hogarth L (2011). Evaluation of un-medicated, self-paced alcohol withdrawal. PLoS One, 6(7). Abstract.  Author URL.  Full text.
Chase HW, Hogarth L (2011). Impulsivity and symptoms of nicotine dependence in a young adult population. Nicotine Tob Res, 13(12), 1321-1325. Abstract.  Author URL.  Full text.
Hogarth L, Chase HW (2011). Parallel goal-directed and habitual control of human drug-seeking: implications for dependence vulnerability. J Exp Psychol Anim Behav Process, 37(3), 261-276. Abstract.  Author URL.
Trick L, Hogarth L, Duka T (2011). Prediction and uncertainty in human Pavlovian to instrumental transfer. J Exp Psychol Learn Mem Cogn, 37(3), 757-765. Abstract.  Author URL.
Chase HW, Eickhoff SB, Laird AR, Hogarth L (2011). The neural basis of drug stimulus processing and craving: an activation likelihood estimation meta-analysis. Biol Psychiatry, 70(8), 785-793. Abstract.  Author URL.
Hogarth L (2011). The role of impulsivity in the aetiology of drug dependence: reward sensitivity versus automaticity. Psychopharmacology (Berl), 215(3), 567-580. Abstract.  Author URL.  Full text.
Hogarth L, Dickinson A, Duka T (2010). The associative basis of cue-elicited drug taking in humans. Psychopharmacology (Berl), 208(3), 337-351. Abstract.  Author URL.
Hogarth L, Dickinson A, Duka T (2009). Detection versus sustained attention to drug cues have dissociable roles in mediating drug seeking behavior. Exp Clin Psychopharmacol, 17(1), 21-30. Abstract.  Author URL.
Hogarth L, Dickinson A, Austin A, Brown C, Duka T (2008). Attention and expectation in human predictive learning: the role of uncertainty. Q J Exp Psychol (Hove), 61(11), 1658-1668. Abstract.  Author URL.
Hogarth L, Dickinson A, Janowski M, Nikitina A, Duka T (2008). The role of attentional bias in mediating human drug-seeking behaviour. Psychopharmacology (Berl), 201(1), 29-41. Abstract.  Author URL.
Hogarth L, Dickinson A, Wright A, Kouvaraki M, Duka T (2007). The role of drug expectancy in the control of human drug seeking. J Exp Psychol Anim Behav Process, 33(4), 484-496. Abstract.  Author URL.
Hogarth L, Dickinson A, Hutton SB, Bamborough H, Duka T (2006). Contingency knowledge is necessary for learned motivated behaviour in humans: relevance for addictive behaviour. Addiction, 101(8), 1153-1166. Abstract.  Author URL.
Hogarth L, Dickinson A, Hutton SB, Elbers N, Duka T (2006). Drug expectancy is necessary for stimulus control of human attention, instrumental drug-seeking behaviour and subjective pleasure. Psychopharmacology (Berl), 185(4), 495-504. Abstract.  Author URL.
Hogarth L, Duka T (2006). Human nicotine conditioning requires explicit contingency knowledge: is addictive behaviour cognitively mediated?. Psychopharmacology (Berl), 184(3-4), 553-566. Abstract.  Author URL.
Hogarth L, Dickinson A, Duka T (2005). Explicit knowledge of stimulus-outcome contingencies and stimulus control of selective attention and instrumental action in human smoking behaviour. Psychopharmacology (Berl), 177(4), 428-437. Abstract.  Author URL.
Stephens DN, Ripley TL, Borlikova G, Schubert M, Albrecht D, Hogarth L, Duka T (2005). Repeated ethanol exposure and withdrawal impairs human fear conditioning and depresses long-term potentiation in rat amygdala and hippocampus. Biol Psychiatry, 58(5), 392-400. Abstract.  Author URL.
Hogarth LC, Mogg K, Bradley BP, Duka T, Dickinson A (2003). Attentional orienting towards smoking-related stimuli. Behavioural Pharmacology, 14(2), 153-160. Abstract.
Hogarth LC, Mogg K, Bradley BP, Duka T, Dickinson A (2003). Attentional orienting towards smoking-related stimuli. Behavioural Pharmacology, 14, 153-160.
Hogarth L, Dickinson A, Duka T (2003). Discriminative stimuli that control instrumental tobacco-seeking by human smokers also command selective attention. Psychopharmacology (Berl), 168(4), 435-445. Abstract.  Author URL.

Chapters

Hogarth L, Troisi JR (2015). A hierarchical instrumental decision theory of nicotine dependence. In  (Ed) , 165-191.  Abstract.  Author URL.  Full text.
Hogarth L, Chase HW (2013). Vulnerabilities underlying human drug dependence: Goal valuation versus habit learning. In  (Ed) , 75-101.
Hogarth L, Dickinson A, Duka T (2010). Selective attention to conditioned stimuli in human discrimination learning: Untangling the effect of outcome prediction, valence, arousal and uncertainty. In Mitchell CJ, Pelley MEL (Eds.) Attention and Associative Learning, Oxford University Press, 71-98.  Abstract.  Full text.

Conferences

Rose AK, Hogarth L, Brown K (2012). ATTENTIONAL PROCESSES AND THE ABILITY OF ALCOHOL CUES TO TRIGGER HABIT-LIKE ALCOHOL-SEEKING BEHAVIOUR.  Author URL.
Hogarth L, Rose AK (2012). GOAL-DIRECTED CONTROL OVER ACTION SELECTION IN HUMANS IS IMPAIRED BY ACUTE ALCOHOL ADMINISTRATION AND ALCOHOL CUES.  Author URL.
Rose AK, Hogarth L, Brown K (2012). THE ROLE OF ATTENTION IN MEDIATING GOAL-DIRECTED ALCOHOL SEEKING.  Author URL.
Norman N, Hogarth L, Panlilio L, Shoaib M (2011). ESTABLISHING CONCURRENT CHOICE PROCEDURES WITH INTRAVENOUS NICOTINE AND SUCROSE IN RATS.  Author URL.
Norman NA, Hogarth L, Panlilio L, Shoaib M (2011). ESTABLISHING CONCURRENT CHOICE PROCEDURES WITH INTRAVENOUS NICOTINE AND SUCROSE IN RATS.  Author URL.
Esfandiari A, Shoaib M, Hogarth L, Panlilio L (2011). ESTABLISHING PAVLOVIAN TO INSTRUMENTAL TRANSFER (PIT) WITH INTRAVENOUS NICOTINE AND SUCROSE IN RATS.  Author URL.
Rose AK, Hogarth L (2011). THE ROLE OF CHOICE IN ALCOHOL DEPENDENCE.  Author URL.
Duka T, Townshend J, Hogarth L, Stephens D (2007). Impaired learning of conditioned fear in alcoholics with a history of multiple detoxifications and in binge drinkers.  Author URL.
Hogarth L, Dickinson A, Wright A, Kouvaraki M, Duka T (2007). The role of drug expectancy in the control of human drug seeking.  Author URL.
Hogarth L, Dickinson A, Hutton SB, Bamborough H, Duka T (2005). Stimulus control of human selective attention and instrumental avoidance behaviour depends upon explicit contingency knowledge.  Author URL.
Hogarth L, Dickinson A, Hutton SB, Duka T (2005). The control of human selective attention by cues associated with nicotine.  Author URL.

Publications by year


In Press

Hardy L, Hogarth L (In Press). A novel concurrent pictorial choice model of mood-induced relapse in hazardous drinkers. Experimental and clinical psychopharmacology Full text.
Rose AK, Brown K, MacKillop J, Field M, Hogarth L (In Press). Alcohol devaluation has dissociable effects on distinct components of alcohol behaviour. Psychopharmacology Full text.
Hogarth L, Mathew AR, Hitsman B (In Press). Current major depression is associated with greater sensitivity to the motivational effect of both negative mood induction and abstinence on tobacco-seeking behavior. Drug and Alcohol Dependence Full text.
Hogarth L, Seabrooke T, Edmunds C, Mitchell C (In Press). Goal-directed control in Pavlovian-instrumental transfer. Journal of Experimental Psychology: Animal Learning and Cognition Full text.
Hogarth L, Lam-Cassettari C, Pacitti H, Currah T, Mahlberg J, Hartley L, Moustafa A (In Press). Intact goal-directed control in treatment-seeking drug users indexed by outcome-devaluation and Pavlovian to instrumental transfer: Critique of habit theory. European Journal of Neuroscience Full text.
Hogarth L, Shuai R, Bakou AE, Hardy L (In Press). Ultra-brief breath counting (mindfulness) training promotes recovery from stress-induced alcohol-seeking in student drinkers. Addictive Behaviors Full text.

2019

Seabrooke T, Wills AJ, Hogarth L, Mitchell CJ (2019). Automaticity and cognitive control: Effects of cognitive load on cue-controlled reward choice. Quarterly journal of experimental psychology (2006), 72(6), 1507-1521. Abstract.  Full text.
Hogarth L (2019). Cue-elicited craving and human Pavlovian-to-instrumental transfer. Addiction Research & Theory
Hogarth L, Hardy L, Bakou A, Mahlberg J, Weidemann G, Cashel S, Moustafa AA (2019). Negative Mood Induction Increases Choice of Heroin Versus Food Pictures in Opiate-Dependent Individuals: Correlation with Self-Medication Coping Motives and Subjective Reactivity. FRONTIERS IN PSYCHIATRY, 10 Author URL.  Full text.
Hogarth L (2019). Relationship between childhood abuse and substance misuse problems is mediated by substance use coping motives, in school attending South African adolescents. Drug and Alcohol Dependence Full text.

2018

Hogarth L (2018). A Critical Review of Habit Theory of Drug Dependence.
Hogarth L (2018). A concurrent pictorial drug choice task marks multiple risk factors in treatment-engaged smokers and drinkers. Behavioural Pharmacology Full text.
Hogarth L (2018). Alcohol use disorder symptoms are associated with greater relative value ascribed to alcohol, but not greater discounting of costs imposed on alcohol. Psychopharmacology Full text.
Miele A, Thompson M, Jao NC, Kalhan R, Leone F, Hogarth L, Hitsman B, Schnoll R (2018). Cancer Patients Enrolled in a Smoking Cessation Clinical Trial: Characteristics and Correlates of Smoking Rate and Nicotine Dependence. Journal of addiction Full text.
Hogarth L (2018). Controlled and automatic learning processes in addiction.
Hardy L, Josephy K, McAndrew A, Hawksley P, Hartley L, Hogarth L (2018). Evaluation of the Peninsula Alcohol and Violence Programme (PAVP) with violent offenders. Addiction Research & Theory, 0, 1-8. Abstract.  Full text.
Pritchard TL, Weidemann G, Hogarth L (2018). Negative emotional appraisal selectively disrupts retrieval of expected outcome values required for goal-directed instrumental choice. Cogn Emot, 32(4), 843-851. Abstract.  Author URL.  Full text.
Hogarth L (2018). Negative mood-induced alcohol-seeking is greater in young adults who report depression symptoms, drinking to cope, and subjective reactivity. Experimental and Clinical Psychopharmacology Full text.

2017

Mathew AR, Hogarth L, Leventhal AM, Cook JW, Hitsman B (2017). Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model. Addiction, 112(3), 401-412. Abstract.  Author URL.  Full text.
Hogarth L, Hardy L (2017). Depressive statements prime goal-directed alcohol-seeking in individuals who report drinking to cope with negative affect. Psychopharmacology, 235, 269-279. Full text.
Hardy L, Mitchell C, Seabrooke T, Hogarth L (2017). Drug cue reactivity involves hierarchical instrumental learning: evidence from a biconditional Pavlovian to instrumental transfer task. Psychopharmacology (Berl), 234(13), 1977-1984. Abstract.  Author URL.  Full text.
Seabrooke T, Le Pelley ME, Hogarth L, Mitchell CJ (2017). Evidence of a goal-directed process in human Pavlovian-instrumental transfer. J Exp Psychol Anim Learn Cogn, 43(4), 377-387. Abstract.  Author URL.  Full text.
Myers CE, Rego J, Haber P, Morley K, Beck KD, Hogarth L, Moustafa AA (2017). Learning and generalization from reward and punishment in opioid addiction. Behav Brain Res, 317, 122-131. Abstract.  Author URL.  Full text.
Mahlberg J, Haber P, Morley K, Weidemann G, Hogarth L, Beck KD, Myers CE, Moustafa AA (2017). Reward and punishment-based compound cue learning and generalization in opiate dependency. Exp Brain Res, 235(10), 3153-3162. Abstract.  Author URL.  Full text.

2016

Mathew AR, Hogarth L, Leventhal AM, Cook JW, Hitsman B (2016). Cigarette smoking and depression comorbidity: systematic review & proposed theoretical model. Addiction
Sheynin J, Moustafa AA, Beck KD, Servatius RJ, Casbolt PA, Haber P, Elsayed M, Hogarth L, Myers CE (2016). Exaggerated acquisition and resistance to extinction of avoidance behavior in treated heroin-dependent men. J Clin Psychiatry, 77(3), 386-394. Abstract.  Author URL.
Myers CE, Sheynin J, Balsdon T, Luzardo A, Beck KD, Hogarth L, Haber P, Moustafa AA (2016). Probabilistic reward- and punishment-based learning in opioid addiction: Experimental and computational data. Behav Brain Res, 296, 240-248. Abstract.  Author URL.
Seabrooke T, Hogarth L, Mitchell CJ (2016). The propositional basis of cue-controlled reward seeking. Q J Exp Psychol (Hove), 69(12), 2452-2470. Abstract.  Author URL.  Full text.
Field M, Werthmann J, Franken I, Hofmann W, Hogarth L, Roefs A (2016). The role of attentional bias in obesity and addiction. Health Psychol, 35(8), 767-780. Abstract.  Author URL.

2015

Hogarth L, Troisi JR (2015). A hierarchical instrumental decision theory of nicotine dependence. In  (Ed) , 165-191.  Abstract.  Author URL.  Full text.
Panlilio LV, Hogarth L, Shoaib M (2015). Concurrent access to nicotine and sucrose in rats. Psychopharmacology (Berl), 232(8), 1451-1460. Abstract.  Author URL.  Full text.
Maynard OM, Leonards U, Attwood AS, Bauld L, Hogarth L, Munafò MR (2015). Effects of first exposure to plain cigarette packaging on smoking behaviour and attitudes: a randomised controlled study. BMC Public Health, 15(1). Abstract.  Full text.
Hogarth L, He Z, Chase HW, Wills AJ, Troisi J, Leventhal AM, Mathew AR, Hitsman B (2015). Negative mood reverses devaluation of goal-directed drug-seeking favouring an incentive learning account of drug dependence. Psychopharmacology (Berl), 232(17), 3235-3247. Abstract.  Author URL.  Full text.
Hogarth L, Maynard OM, Munafò MR (2015). Plain cigarette packs do not exert Pavlovian to instrumental transfer of control over tobacco-seeking. Addiction, 110(1), 174-182. Abstract.  Author URL.  Full text.

2014

Martinovic J, Jones A, Christiansen P, Rose AK, Hogarth L, Field M (2014). Electrophysiological responses to alcohol cues are not associated with Pavlovian-to-instrumental transfer in social drinkers. PLoS One, 9(4). Abstract.  Author URL.  Full text.
Hogarth L, Retzler C, Munafò MR, Tran DMD, Troisi JR, Rose AK, Jones A, Field M (2014). Extinction of cue-evoked drug-seeking relies on degrading hierarchical instrumental expectancies. Behav Res Ther, 59, 61-70. Abstract.  Author URL.  Full text.
Maynard OM, Leonards U, Attwood AS, Bauld L, Hogarth L, Munafò MR (2014). Plain packaging of cigarettes and smoking behavior: study protocol for a randomized controlled study. Trials, 15 Abstract.  Author URL.  Full text.

2013

Hogarth L, Balleine BW, Corbit LH, Killcross S (2013). Associative learning mechanisms underpinning the transition from recreational drug use to addiction. Ann N Y Acad Sci, 1282, 12-24. Abstract.  Author URL.  Full text.
Hogarth L, Stillwell DJ, Tunney RJ (2013). BIS impulsivity and acute nicotine exposure are associated with discounting global consequences in the Harvard game. Hum Psychopharmacol, 28(1), 72-79. Abstract.  Author URL.
Hitsman B, Hogarth L, Tseng L-J, Teige JC, Shadel WG, DiBenedetti DB, Danto S, Lee TC, Price LH, Niaura R, et al (2013). Dissociable effect of acute varenicline on tonic versus cue-provoked craving in non-treatment-motivated heavy smokers. Drug and Alcohol Dependence, 130, 135-141.
Chase HW, Mackillop J, Hogarth L (2013). Isolating behavioural economic indices of demand in relation to nicotine dependence. Psychopharmacology (Berl), 226(2), 371-380. Abstract.  Author URL.
Hogarth L, Field M, Rose AK (2013). Phasic transition from goal-directed to habitual control over drug-seeking produced by conflicting reinforcer expectancy. Addiction Biology, 18, 88-97. Full text.
Rose AK, Brown K, Field M, Hogarth L (2013). The contributions of value-based decision-making and attentional bias to alcohol-seeking following devaluation. Addiction, 108(7), 1241-1249. Abstract.  Author URL.
Hogarth L, Chase HW (2013). Vulnerabilities underlying human drug dependence: Goal valuation versus habit learning. In  (Ed) , 75-101.

2012

Rose AK, Hogarth L, Brown K (2012). ATTENTIONAL PROCESSES AND THE ABILITY OF ALCOHOL CUES TO TRIGGER HABIT-LIKE ALCOHOL-SEEKING BEHAVIOUR.  Author URL.
Hogarth L, Attwood AS, Bate HA, Munafò MR (2012). Acute alcohol impairs human goal-directed action. Biol Psychol, 90(2), 154-160. Abstract.  Author URL.
Hogarth L, Chase HW (2012). Evaluating psychological markers for human nicotine dependence: tobacco choice, extinction, and Pavlovian-to-instrumental transfer. Exp Clin Psychopharmacol, 20(3), 213-224. Abstract.  Author URL.
Hogarth L, Rose AK (2012). GOAL-DIRECTED CONTROL OVER ACTION SELECTION IN HUMANS IS IMPAIRED BY ACUTE ALCOHOL ADMINISTRATION AND ALCOHOL CUES.  Author URL.
Hogarth L (2012). Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: evidence for independent additive controllers. J Exp Psychol Anim Behav Process, 38(3), 266-278. Abstract.  Author URL.  Full text.
Hogarth L, Chase HW, Baess K (2012). Impaired goal-directed behavioural control in human impulsivity. Q J Exp Psychol (Hove), 65(2), 305-316. Abstract.  Author URL.  Full text.
Jones A, Hogarth L, Christiansen P, Rose AK, Martinovic J, Field M (2012). Reward expectancy promotes generalized increases in attentional bias for rewarding stimuli. Q J Exp Psychol (Hove), 65(12), 2333-2342. Abstract.  Author URL.
Rose AK, Hogarth L, Brown K (2012). THE ROLE OF ATTENTION IN MEDIATING GOAL-DIRECTED ALCOHOL SEEKING.  Author URL.

2011

Field M, Hogarth L, Bleasdale D, Wright P, Fernie G, Christiansen P (2011). Alcohol expectancy moderates attentional bias for alcohol cues in light drinkers. Addiction, 106(6), 1097-1103. Abstract.  Author URL.
Haselgrove M, Hogarth L (2011). Clinical Applications of Learning Theory., Psychology Press. Abstract.
Norman N, Hogarth L, Panlilio L, Shoaib M (2011). ESTABLISHING CONCURRENT CHOICE PROCEDURES WITH INTRAVENOUS NICOTINE AND SUCROSE IN RATS.  Author URL.
Norman NA, Hogarth L, Panlilio L, Shoaib M (2011). ESTABLISHING CONCURRENT CHOICE PROCEDURES WITH INTRAVENOUS NICOTINE AND SUCROSE IN RATS.  Author URL.
Esfandiari A, Shoaib M, Hogarth L, Panlilio L (2011). ESTABLISHING PAVLOVIAN TO INSTRUMENTAL TRANSFER (PIT) WITH INTRAVENOUS NICOTINE AND SUCROSE IN RATS.  Author URL.
Craig M, Pennacchia A, Wright NR, Chase HW, Hogarth L (2011). Evaluation of un-medicated, self-paced alcohol withdrawal. PLoS One, 6(7). Abstract.  Author URL.  Full text.
Chase HW, Hogarth L (2011). Impulsivity and symptoms of nicotine dependence in a young adult population. Nicotine Tob Res, 13(12), 1321-1325. Abstract.  Author URL.  Full text.
Hogarth L, Chase HW (2011). Parallel goal-directed and habitual control of human drug-seeking: implications for dependence vulnerability. J Exp Psychol Anim Behav Process, 37(3), 261-276. Abstract.  Author URL.
Trick L, Hogarth L, Duka T (2011). Prediction and uncertainty in human Pavlovian to instrumental transfer. J Exp Psychol Learn Mem Cogn, 37(3), 757-765. Abstract.  Author URL.
Rose AK, Hogarth L (2011). THE ROLE OF CHOICE IN ALCOHOL DEPENDENCE.  Author URL.
Chase HW, Eickhoff SB, Laird AR, Hogarth L (2011). The neural basis of drug stimulus processing and craving: an activation likelihood estimation meta-analysis. Biol Psychiatry, 70(8), 785-793. Abstract.  Author URL.
Hogarth L (2011). The role of impulsivity in the aetiology of drug dependence: reward sensitivity versus automaticity. Psychopharmacology (Berl), 215(3), 567-580. Abstract.  Author URL.  Full text.

2010

Hogarth L, Dickinson A, Duka T (2010). Selective attention to conditioned stimuli in human discrimination learning: Untangling the effect of outcome prediction, valence, arousal and uncertainty. In Mitchell CJ, Pelley MEL (Eds.) Attention and Associative Learning, Oxford University Press, 71-98.  Abstract.  Full text.
Hogarth L, Dickinson A, Duka T (2010). The associative basis of cue-elicited drug taking in humans. Psychopharmacology (Berl), 208(3), 337-351. Abstract.  Author URL.

2009

Hogarth L, Dickinson A, Duka T (2009). Detection versus sustained attention to drug cues have dissociable roles in mediating drug seeking behavior. Exp Clin Psychopharmacol, 17(1), 21-30. Abstract.  Author URL.

2008

Hogarth L, Dickinson A, Austin A, Brown C, Duka T (2008). Attention and expectation in human predictive learning: the role of uncertainty. Q J Exp Psychol (Hove), 61(11), 1658-1668. Abstract.  Author URL.
Hogarth L, Dickinson A, Janowski M, Nikitina A, Duka T (2008). The role of attentional bias in mediating human drug-seeking behaviour. Psychopharmacology (Berl), 201(1), 29-41. Abstract.  Author URL.

2007

Duka T, Townshend J, Hogarth L, Stephens D (2007). Impaired learning of conditioned fear in alcoholics with a history of multiple detoxifications and in binge drinkers.  Author URL.
Hogarth L, Dickinson A, Wright A, Kouvaraki M, Duka T (2007). The role of drug expectancy in the control of human drug seeking.  Author URL.
Hogarth L, Dickinson A, Wright A, Kouvaraki M, Duka T (2007). The role of drug expectancy in the control of human drug seeking. J Exp Psychol Anim Behav Process, 33(4), 484-496. Abstract.  Author URL.

2006

Hogarth L, Dickinson A, Hutton SB, Bamborough H, Duka T (2006). Contingency knowledge is necessary for learned motivated behaviour in humans: relevance for addictive behaviour. Addiction, 101(8), 1153-1166. Abstract.  Author URL.
Hogarth L, Dickinson A, Hutton SB, Elbers N, Duka T (2006). Drug expectancy is necessary for stimulus control of human attention, instrumental drug-seeking behaviour and subjective pleasure. Psychopharmacology (Berl), 185(4), 495-504. Abstract.  Author URL.
Hogarth L, Duka T (2006). Human nicotine conditioning requires explicit contingency knowledge: is addictive behaviour cognitively mediated?. Psychopharmacology (Berl), 184(3-4), 553-566. Abstract.  Author URL.

2005

Hogarth L, Dickinson A, Duka T (2005). Explicit knowledge of stimulus-outcome contingencies and stimulus control of selective attention and instrumental action in human smoking behaviour. Psychopharmacology (Berl), 177(4), 428-437. Abstract.  Author URL.
Stephens DN, Ripley TL, Borlikova G, Schubert M, Albrecht D, Hogarth L, Duka T (2005). Repeated ethanol exposure and withdrawal impairs human fear conditioning and depresses long-term potentiation in rat amygdala and hippocampus. Biol Psychiatry, 58(5), 392-400. Abstract.  Author URL.
Hogarth L, Dickinson A, Hutton SB, Bamborough H, Duka T (2005). Stimulus control of human selective attention and instrumental avoidance behaviour depends upon explicit contingency knowledge.  Author URL.
Hogarth L, Dickinson A, Hutton SB, Duka T (2005). The control of human selective attention by cues associated with nicotine.  Author URL.

2003

Hogarth LC, Mogg K, Bradley BP, Duka T, Dickinson A (2003). Attentional orienting towards smoking-related stimuli. Behavioural Pharmacology, 14(2), 153-160. Abstract.
Hogarth LC, Mogg K, Bradley BP, Duka T, Dickinson A (2003). Attentional orienting towards smoking-related stimuli. Behavioural Pharmacology, 14, 153-160.
Hogarth L, Dickinson A, Duka T (2003). Discriminative stimuli that control instrumental tobacco-seeking by human smokers also command selective attention. Psychopharmacology (Berl), 168(4), 435-445. Abstract.  Author URL.

Lee_Hogarth Details from cache as at 2019-12-06 17:13:55

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External Engagement and Impact

Editorial responsibilities


Other

Public dissemination

British Science Festival, Birmingham, UK. From Pavlov to Present. 2010.


Workshops organised

Teaching

  • Module convenor for third year seminar Psychology of Addiction - PSY3437
  • Module convenor for third year research projects - PSY3401
  • Co-convernor for second year Biological Basis of Behaviour - PSY2304
  • Supervisor for BSc, MSc and PhD research projects
  • Organiser of BPS South West Undergraduate Psychology Conference 

Modules

2019/20


Supervision / Group

Postgraduate researchers

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