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Dr Alexander Shaw

Dr Alexander Shaw

Lecturer

 Washington Singer 112

 

Washington Singer Laboratories, University of Exeter, Perry Road, Prince of Wales Road, Exeter, EX4 4QG, UK

 Office hours:

https://linktr.ee/alexandershaw

Overview

I am a Lecturer in the school of Psychology. My research aims to unpick the pathophysiology of psychiatric disease using multimodal imaging (M/EEG, MRI, PET), pharmaco-imaging and computational modelling. I also work on developing increasingly detailed, neurophysiologically-inspired models of the brain and optimisation routines that estimate the (synaptic) parameters of such models in light of recorded data. I am convinced this multi-scale and multimodal approach is the key to new and effective treatments for psychiatry.

I am interested in hearing from prospective PhD students.

Links

Research

Links


Publications

Key publications | Publications by category | Publications by year

Key publications


Adams NE, Hughes LE, Rouse MA, Phillips HN, Shaw AD, Murley AG, Cope TE, Bevan-Jones WR, Passamonti L, Street D, et al (2021). GABAergic cortical network physiology in frontotemporal lobar degeneration. Brain, 144(7), 2135-2145. Abstract.
Sumner RL, Spriggs MJ, Shaw AD (2021). Modelling thalamocortical circuitry shows that visually induced LTP changes laminar connectivity in human visual cortex. PLOS Computational Biology, 17(1), e1008414-e1008414. Abstract.
Adams NE, Hughes LE, Phillips HN, Shaw AD, Murley AG, Nesbitt D, Cope TE, Bevan-Jones WR, Passamonti L, Rowe JB, et al (2020). GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography. The Journal of Neuroscience, 40(8), 1640-1649.
Shaw AD, Muthukumaraswamy SD, Saxena N, Sumner RL, Adams NE, Moran RJ, Singh KD (2020). Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine. NeuroImage, 221, 117189-117189.
Shaw AD, Hughes LE, Moran R, Coyle-Gilchrist I, Rittman T, Rowe JB (2019). In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: a Platform for Experimental Medicine Studies. Cerebral Cortex, 31(3), 1837-1847. Abstract.
Shaw AD, Knight L, Freeman TCA, Williams GM, Moran RJ, Friston KJ, Walters JTR, Singh KD (2019). Oscillatory, Computational, and Behavioral Evidence for Impaired GABAergic Inhibition in Schizophrenia. Schizophrenia Bulletin

Publications by category


Journal articles

Saxena N, Shaw AD, Richmond L, Babic A, Singh KD, Hall JE, Wise RG, Muthukumaraswamy SD (In Press). A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography.  Abstract.
Shaw AD, Chandler HL, Hamandi K, Muthukumaraswamy SD, Hammers A, Singh KD (In Press). GABAA receptor mapping in human using non-invasive electrophysiology.  Abstract.
Shaw AD, Muthukumaraswamy SD, Saxena N, Sumner RL, Adams N, Moran RJ, Singh KD (In Press). Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine.  Abstract.
Sumner RL, Spriggs MJ, Shaw AD (In Press). Modelling thalamocortical circuitry shows visually induced LTP changes laminar connectivity in human visual cortex.  Abstract.
Adams NE, Hughes LE, Rouse MA, Phillips HN, Shaw AD, Murley AG, Cope TE, Bevan-Jones WR, Passamonti L, Street D, et al (2021). GABAergic cortical network physiology in frontotemporal lobar degeneration. Brain, 144(7), 2135-2145. Abstract.
Sumner RL, Spriggs MJ, Shaw AD (2021). Modelling thalamocortical circuitry shows that visually induced LTP changes laminar connectivity in human visual cortex. PLOS Computational Biology, 17(1), e1008414-e1008414. Abstract.
Shaw AD, Chandler HL, Hamandi K, Muthukumaraswamy SD, Hammers A, Singh KD (2021). Tiagabine induced modulation of oscillatory connectivity and activity match PET-derived, canonical GABA-A receptor distributions. European Neuropsychopharmacology, 50, 34-45.
Adams NE, Hughes LE, Phillips HN, Shaw AD, Murley AG, Nesbitt D, Cope TE, Bevan-Jones WR, Passamonti L, Rowe JB, et al (2020). GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography. The Journal of Neuroscience, 40(8), 1640-1649.
Shaw AD, Muthukumaraswamy SD, Saxena N, Sumner RL, Adams NE, Moran RJ, Singh KD (2020). Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine. NeuroImage, 221, 117189-117189.
Routley B, Shaw A, Muthukumaraswamy SD, Singh KD, Hamandi K (2020). Juvenile myoclonic epilepsy shows increased posterior theta, and reduced sensorimotor beta resting connectivity. Epilepsy Research, 163, 106324-106324.
Shaw AD, Hughes LE, Moran R, Coyle-Gilchrist I, Rittman T, Rowe JB (2019). In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: a Platform for Experimental Medicine Studies. Cerebral Cortex, 31(3), 1837-1847. Abstract.
Shaw AD, Knight L, Freeman TCA, Williams GM, Moran RJ, Friston KJ, Walters JTR, Singh KD (2019). Oscillatory, Computational, and Behavioral Evidence for Impaired GABAergic Inhibition in Schizophrenia. Schizophrenia Bulletin
Sumner RL, McMillan RL, Shaw AD, Singh KD, Sundram F, Muthukumaraswamy SD (2018). Peak visual gamma frequency is modified across the healthy menstrual cycle. Human Brain Mapping, 39(8), 3187-3202.
Shaw AD, Moran RJ, Muthukumaraswamy SD, Brealy J, Linden DE, Friston KJ, Singh KD (2017). Neurophysiologically-informed markers of individual variability and pharmacological manipulation of human cortical gamma. NeuroImage, 161, 19-31.
Muthukumaraswamy SD, Shaw AD, Jackson LE, Hall J, Moran R, Saxena N (2015). Evidence that subanesthetic doses of ketamine cause sustained disruptions of NMDA and AMPA-mediated frontoparietal connectivity in humans. Journal of Neuroscience, 35(33), 11694-11706. Abstract.
Shaw AD, Saxena N, E. Jackson L, Hall JE, Singh KD, Muthukumaraswamy SD (2015). Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex. European Neuropsychopharmacology, 25(8), 1136-1146.
Robson SE, Muthukumarawswamy SD, John Evans C, Shaw A, Brealy J, Davis B, McNamara G, Perry G, Singh KD (2015). Structural and neurochemical correlates of individual differences in gamma frequency oscillations in human visual cortex. Journal of Anatomy, 227(4), 409-417.
Brealy JA, Shaw A, Richardson H, Singh KD, Muthukumaraswamy SD, Keedwell PA (2014). Increased visual gamma power in schizoaffective bipolar disorder. Psychological Medicine, 45(4), 783-794. Abstract.
Shaw A, Brealy J, Richardson H, Muthukumaraswamy SD, Edden RA, John Evans C, Puts NAJ, Singh KD, Keedwell PA (2013). Marked Reductions in Visual Evoked Responses But Not γ-Aminobutyric Acid Concentrations or γ-Band Measures in Remitted Depression. Biological Psychiatry, 73(7), 691-698.

Publications by year


In Press

Saxena N, Shaw AD, Richmond L, Babic A, Singh KD, Hall JE, Wise RG, Muthukumaraswamy SD (In Press). A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography.  Abstract.
Shaw AD, Chandler HL, Hamandi K, Muthukumaraswamy SD, Hammers A, Singh KD (In Press). GABAA receptor mapping in human using non-invasive electrophysiology.  Abstract.
Shaw AD, Muthukumaraswamy SD, Saxena N, Sumner RL, Adams N, Moran RJ, Singh KD (In Press). Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine.  Abstract.
Sumner RL, Spriggs MJ, Shaw AD (In Press). Modelling thalamocortical circuitry shows visually induced LTP changes laminar connectivity in human visual cortex.  Abstract.

2021

Adams NE, Hughes LE, Rouse MA, Phillips HN, Shaw AD, Murley AG, Cope TE, Bevan-Jones WR, Passamonti L, Street D, et al (2021). GABAergic cortical network physiology in frontotemporal lobar degeneration. Brain, 144(7), 2135-2145. Abstract.
Sumner RL, Spriggs MJ, Shaw AD (2021). Modelling thalamocortical circuitry shows that visually induced LTP changes laminar connectivity in human visual cortex. PLOS Computational Biology, 17(1), e1008414-e1008414. Abstract.
Shaw AD, Chandler HL, Hamandi K, Muthukumaraswamy SD, Hammers A, Singh KD (2021). Tiagabine induced modulation of oscillatory connectivity and activity match PET-derived, canonical GABA-A receptor distributions. European Neuropsychopharmacology, 50, 34-45.

2020

Adams NE, Hughes LE, Phillips HN, Shaw AD, Murley AG, Nesbitt D, Cope TE, Bevan-Jones WR, Passamonti L, Rowe JB, et al (2020). GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography. The Journal of Neuroscience, 40(8), 1640-1649.
Shaw AD, Muthukumaraswamy SD, Saxena N, Sumner RL, Adams NE, Moran RJ, Singh KD (2020). Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine. NeuroImage, 221, 117189-117189.
Routley B, Shaw A, Muthukumaraswamy SD, Singh KD, Hamandi K (2020). Juvenile myoclonic epilepsy shows increased posterior theta, and reduced sensorimotor beta resting connectivity. Epilepsy Research, 163, 106324-106324.

2019

Shaw AD, Hughes LE, Moran R, Coyle-Gilchrist I, Rittman T, Rowe JB (2019). In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: a Platform for Experimental Medicine Studies. Cerebral Cortex, 31(3), 1837-1847. Abstract.
Shaw AD, Knight L, Freeman TCA, Williams GM, Moran RJ, Friston KJ, Walters JTR, Singh KD (2019). Oscillatory, Computational, and Behavioral Evidence for Impaired GABAergic Inhibition in Schizophrenia. Schizophrenia Bulletin

2018

Sumner RL, McMillan RL, Shaw AD, Singh KD, Sundram F, Muthukumaraswamy SD (2018). Peak visual gamma frequency is modified across the healthy menstrual cycle. Human Brain Mapping, 39(8), 3187-3202.

2017

Shaw AD, Moran RJ, Muthukumaraswamy SD, Brealy J, Linden DE, Friston KJ, Singh KD (2017). Neurophysiologically-informed markers of individual variability and pharmacological manipulation of human cortical gamma. NeuroImage, 161, 19-31.

2015

Muthukumaraswamy SD, Shaw AD, Jackson LE, Hall J, Moran R, Saxena N (2015). Evidence that subanesthetic doses of ketamine cause sustained disruptions of NMDA and AMPA-mediated frontoparietal connectivity in humans. Journal of Neuroscience, 35(33), 11694-11706. Abstract.
Shaw AD, Saxena N, E. Jackson L, Hall JE, Singh KD, Muthukumaraswamy SD (2015). Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex. European Neuropsychopharmacology, 25(8), 1136-1146.
Robson SE, Muthukumarawswamy SD, John Evans C, Shaw A, Brealy J, Davis B, McNamara G, Perry G, Singh KD (2015). Structural and neurochemical correlates of individual differences in gamma frequency oscillations in human visual cortex. Journal of Anatomy, 227(4), 409-417.

2014

Brealy JA, Shaw A, Richardson H, Singh KD, Muthukumaraswamy SD, Keedwell PA (2014). Increased visual gamma power in schizoaffective bipolar disorder. Psychological Medicine, 45(4), 783-794. Abstract.

2013

Shaw A, Brealy J, Richardson H, Muthukumaraswamy SD, Edden RA, John Evans C, Puts NAJ, Singh KD, Keedwell PA (2013). Marked Reductions in Visual Evoked Responses But Not γ-Aminobutyric Acid Concentrations or γ-Band Measures in Remitted Depression. Biological Psychiatry, 73(7), 691-698.

Alex_Shaw Details from cache as at 2021-09-25 15:45:09

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