Psychology

Dr Leor Roseman

Dr Leor Roseman

Senior Lecturer

 L.Roseman@exeter.ac.uk

 Washington Singer Room 225

 

Washington Singer Laboratories, University of Exeter, Perry Road, Prince of Wales Road, Exeter, EX4 4QG, UK

Overview

I am a Senior Lecturer and Psychedelic Researcher at the department of psychology. I am fascinated by the ways psychedelics modify consciousness from a biopsychosocial perspective. I have previously worked at the Centre for Psychedelic Research, Imperial College London, under the mentorship of Prof. Robin Carhart-Harris and Prof. David Nutt. I have been in the midst of a so-called psychedelic revolution, supporting the foundational work of a re-emerging research field.

My interdisciplinary research covers neuroscience, psychology, phenomenology, anthropology and conflict resolution, using a wide array of research methods such as fMRI, quantitative, qualitative, microphenomenology, ethnographic, and participatory research.

My main research interests are

  • The communal and social use of psychedelics. I am interested in how psychedelics enhance connectedness, group bonding (communitas), sociality, and can serve as a social cure.
  • The potential use of psychedelics for peacebuilding. I study ayahuasca groups of Israelis and Palestinians. In an ethnographic-phenomenological work, I described intense moments of group unity and identity dissolution; awe-inspiring moments of interfaith and intercultural connection and recognition through music and prayers; and visions of collective trauma and the trauma of the other. From a critical perspective, I argue that too strong of an emphasis on oneness and harmony can preserve the status quo of inequality towards Palestinians by silencing conflictual voices. However, sometimes revelatory events can reveal tensions related to inequality and injustice and motivate people towards changing the status-quo. I am currently working with a group of Palestinian and Israeli activists to create a psychedelic peacebuilding program, and we piloted several such retreats.
  • The neural correlates of the psychedelic state. I am interested in the relation between the psychedelic experience and its neural correlates. Notably, I showed in fMRI how communication patterns increase between usually segregated networks – a result that many labs have replicated since my original publication.
  • The role of the visual cortex in psychedelic imagery. I argue that a core feature of the psychedelic state is enhanced dialogical processes between the visual cortex and higher-level regions.
  • The therapeutic potential of the psychedelic experience. I showed how different psychedelic experiences - such as peak/mystical experiences, emotional breakthroughs, and communitas – relate to long-term clinical changes.
  • Phenomenology. As an enthusiast psychonaut, I am fascinated by the psychedelic experience. I have used micro-phenomenology to study the experience and developed several questionnaires to quantify it.  

For a list of my publications check my Google Scholar profile.

Career

2013-2023: Centre for Psychedelic Research, Imperial College London
                      MRes, PhD, Postdoc & Research Fellow
                      Mentored by Prof. Robin Carhart-Harris & Prof. David Nutt

 

Research group links

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Publications

Journal articles

Luppi AI, Girn M, Rosas FE, Timmermann C, Roseman L, Erritzoe D, Nutt DJ, Stamatakis EA, Spreng RN, Xing L, et al (2024). A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex. Brain, 147(1), 56-80. Abstract.  Author URL.
Vohryzek J, Cabral J, Lord L-D, Fernandes HM, Roseman L, Nutt DJ, Carhart-Harris RL, Deco G, Kringelbach ML (2024). Brain dynamics predictive of response to psilocybin for treatment-resistant depression. Brain Communications, 6(2).
Mediano PAM, Rosas FE, Timmermann C, Roseman L, Nutt DJ, Feilding A, Kaelen M, Kringelbach ML, Barrett AB, Seth AK, et al (2024). Effects of External Stimulation on Psychedelic State Neurodynamics. ACS Chem Neurosci, 15(3), 462-471. Abstract.  Author URL.
Kettner H, Roseman L, Gazzaley A, Carhart-Harris R, Pasquini L (2024). Improvements in well-being following naturalistic psychedelic use and underlying mechanisms of change in older adults: a prospective cohort study. Res Sq Abstract.  Author URL.
Schenberg EE, King F, da Fonseca JE, Roseman L (2024). Is Poorly Assisted Psilocybin Treatment an Increasing Risk?. Am J Psychiatry, 181(1), 75-76.  Author URL.
Barba T, Kettner H, Radu C, Peill JM, Roseman L, Nutt DJ, Erritzoe D, Carhart-Harris R, Giribaldi B (2024). Psychedelics and sexual functioning: a mixed-methods study. Sci Rep, 14(1). Abstract.  Author URL.
Weiss B, Roseman L, Giribaldi B, Nutt DJ, Carhart-Harris RL, Erritzoe D (2024). Unique Psychological Mechanisms Underlying Psilocybin Therapy Versus Escitalopram Treatment in the Treatment of Major Depressive Disorder. International Journal of Mental Health and Addiction Abstract.
Spriggs MJ, Giribaldi B, Lyons T, Rosas FE, Kaertner LS, Buchborn T, Douglass HM, Roseman L, Timmermann C, Erritzoe D, et al (2023). Body mass index (BMI) does not predict responses to psilocybin. JOURNAL OF PSYCHOPHARMACOLOGY, 37(1), 107-116.  Author URL.
Carhart-Harris RL, Chandaria S, Erritzoe DE, Gazzaley A, Girn M, Kettner H, Mediano PAM, Nutt DJ, Rosas FE, Roseman L, et al (2023). Canalization and plasticity in psychopathology. Neuropharmacology, 226 Abstract.
Shukuroglou M, Roseman L, Wall M, Nutt D, Kaelen M, Carhart-Harris R (2023). Changes in music-evoked emotion and ventral striatal functional connectivity after psilocybin therapy for depression. JOURNAL OF PSYCHOPHARMACOLOGY, 37(1), 70-79.  Author URL.
Luppi AII, Vohryzek J, Kringelbach MLL, Mediano PAM, Craig MMM, Adapa R, Carhart-Harris RLL, Roseman L, Pappas I, Peattie ARD, et al (2023). Distributed harmonic patterns of structure-function dependence orchestrate human consciousness. COMMUNICATIONS BIOLOGY, 6(1).  Author URL.
Timmermann C, Roseman L, Haridas S, Rosas FE, Luan L, Kettner H, Martell J, Erritzoe D, Tagliazucchi E, Pallavicini C, et al (2023). Human brain effects of DMT assessed via EEG-fMRI. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 120(13).  Author URL.
Luppi AI, Hansen JY, Adapa R, Carhart-Harris RL, Roseman L, Timmermann C, Golkowski D, Ranft A, Llg R, Jordan D, et al (2023). In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape. SCIENCE ADVANCES, 9(24).  Author URL.
Wall MB, Lam C, Ertl N, Kaelen M, Roseman L, Nutt DJ, Carhart-Harris RL (2023). Increased low-frequency brain responses to music after psilocybin therapy for depression. JOURNAL OF AFFECTIVE DISORDERS, 333, 321-330.  Author URL.
Delli Pizzi S, Chiacchiaretta P, Sestieri C, Ferretti A, Tullo MG, Della Penna S, Martinotti G, Onofrj M, Roseman L, Timmermann C, et al (2023). LSD-induced changes in the functional connectivity of distinct thalamic nuclei. Neuroimage, 283 Abstract.  Author URL.
Delli Pizzi S, Chiacchiaretta P, Sestieri C, Ferretti A, Tullo MG, Granzotto A, Onofrj M, Granzotto A, Roseman L, Timmermann C, et al (2023). Lysergic acid diethylamide-induced modification in the functional connectivity of distinct thalamic subfields. Neuroscience Applied, 2
Aqil M, Roseman L (2023). More than meets the eye: the role of sensory dimensions in psychedelic brain dynamics, experience, and therapeutics. NEUROPHARMACOLOGY, 223  Author URL.
Zafar R, Siegel M, Harding R, Barba T, Agnorelli C, Suseelan S, Roseman L, Wall M, Nutt DJ, Erritzoe D, et al (2023). Psychedelic therapy in the treatment of addiction: the past, present and future. FRONTIERS IN PSYCHIATRY, 14  Author URL.
Mosurinjohn S, Roseman L, Girn M (2023). Psychedelic-induced mystical experiences: an interdisciplinary discussion and critique. FRONTIERS IN PSYCHIATRY, 14  Author URL.
Delli Pizzi S, Chiacchiaretta P, Sestieri C, Ferretti A, Onofrj M, Della Penna S, Roseman L, Timmermann C, Nutt DJ, Carhart-Harris RL, et al (2023). Spatial Correspondence of LSD-Induced Variations on Brain Functioning at Rest with Serotonin Receptor Expression. BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 8(7), 768-776.  Author URL.
Hadar A, David J, Shalit N, Roseman L, Gross R, Sessa B, Lev-Ran S (2023). The Psychedelic Renaissance in Clinical Research: a Bibliometric Analysis of Three Decades of Human Studies with Classical Psychedelics. JOURNAL OF PSYCHOACTIVE DRUGS, 55(1), 1-10.  Author URL.
Singleton SP, Timmermann C, Luppi AI, Eckernäs E, Roseman L, Carhart-Harris RL, Kuceyeski A (2023). Time-resolved network control analysis links reduced control energy under DMT with the serotonin 2a receptor, signal diversity, and subjective experience. bioRxiv Abstract.  Author URL.
Roseman L, Preller KH, Fotiou E, Winkelman MJ (2022). Editorial: Psychedelic sociality: Pharmacological and extrapharmacological perspectives. FRONTIERS IN PHARMACOLOGY, 13  Author URL.
Cruzat J, Sanz Perl Y, Escrichs A, Vohryzek J, Timmermann C, Roseman L, Luppi AI, Ibanez A, Nutt D, Carhart-Harris R, et al (2022). Effects of classic psychedelic drugs on turbulent signatures in brain dynamics. NETWORK NEUROSCIENCE, 6(4), 1104-1124.  Author URL.
Barba T, Buehler S, Kettner H, Radu C, Cunha BG, Nutt DJ, Erritzoe D, Roseman L, Carhart-Harris R (2022). Effects of psilocybin versus escitalopram on rumination and thought suppression in depression. BJPSYCH OPEN, 8(5).  Author URL.
Daws RE, Timmermann C, Giribaldi B, Sexton JD, Wall MB, Erritzoe D, Roseman L, Nutt D, Carhart-Harris R (2022). Increased global integration in the brain after psilocybin therapy for depression. NATURE MEDICINE, 28(4), 844-851.  Author URL.
Singleton SP, Luppi AI, Carhart-Harris RL, Cruzat J, Roseman L, Nutt DJ, Deco G, Kringelbach ML, Stamatakis EA, Kuceyeski A, et al (2022). Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain's control energy landscape. NATURE COMMUNICATIONS, 13(1).  Author URL.
Girn M, Roseman L, Bernhardt B, Smallwood J, Carhart-Harris R, Spreng RN (2022). Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex. NEUROIMAGE, 256  Author URL.
Watts R, Kettner H, Geerts D, Gandy S, Kartner L, Mertens L, Timmermann C, Nour MM, Kaelen M, Nutt D, et al (2022). The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world. PSYCHOPHARMACOLOGY, 239(11), 3461-3483.  Author URL.
Peill JM, Trinci KE, Kettner H, Mertens LJ, Roseman L, Timmermann C, Rosas FE, Lyons T, Carhart-Harris RL (2022). Validation of the Psychological Insight Scale: a new scale to assess psychological insight following a psychedelic experience. JOURNAL OF PSYCHOPHARMACOLOGY, 36(1), 31-45.  Author URL.
Jobst BM, Atasoy S, Ponce-Alvarez A, Sanjuan A, Roseman L, Kaelen M, Carhart-Harris R, Kringelbach ML, Deco G (2021). Increased sensitivity to strong perturbations in a whole-brain model of LSD. NEUROIMAGE, 230  Author URL.
Luppi AI, Carhart-Harris RL, Roseman L, Pappas I, Menon DK, Stamatakis EA (2021). LSD alters dynamic integration and segregation in the human brain. NEUROIMAGE, 227  Author URL.
Roseman L, Karkabi N (2021). On Revelations and Revolutions: Drinking Ayahuasca Among Palestinians Under Israeli Occupation. FRONTIERS IN PSYCHOLOGY, 12  Author URL.
Kaertner LS, Steinborn MB, Kettner H, Spriggs MJ, Roseman L, Buchborn T, Balaet M, Timmermann C, Erritzoe D, Carhart-Harris RL, et al (2021). Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing. Scientific Reports, 11(1). Abstract.
Kettner H, Rosas FE, Timmermann C, Kärtner L, Carhart-Harris RL, Roseman L (2021). Psychedelic Communitas: Intersubjective Experience During Psychedelic Group Sessions Predicts Enduring Changes in Psychological Wellbeing and Social Connectedness. Frontiers in Pharmacology, 12 Abstract.
Timmermann C, Kettner H, Letheby C, Roseman L, Rosas FE, Carhart-Harris RL (2021). Psychedelics alter metaphysical beliefs. SCIENTIFIC REPORTS, 11(1).  Author URL.
Roseman L, Ron Y, Saca A, Ginsberg N, Luan L, Karkabi N, Doblin R, Carhart-Harris R (2021). Relational Processes in Ayahuasca Groups of Palestinians and Israelis. FRONTIERS IN PHARMACOLOGY, 12  Author URL.
Bornemann J, Close JB, Spriggs MJ, Carhart-Harris R, Roseman L (2021). Self-Medication for Chronic Pain Using Classic Psychedelics: a Qualitative Investigation to Inform Future Research. FRONTIERS IN PSYCHIATRY, 12  Author URL.
Close JB, Hajien EC, Watts R, Roseman L, Carhart-Harris RL (2020). Psychedelics and psychological flexibility - Results of a prospective web-survey using the Acceptance and Action Questionnaire II. JOURNAL OF CONTEXTUAL BEHAVIORAL SCIENCE, 16, 37-44.  Author URL.
Varley TF, Carhart-Harris R, Roseman L, Menon DK, Stamatakis EA (2020). Serotonergic psychedelics LSD & psilocybin increase the fractal dimension of cortical brain activity in spatial and temporal domains. NEUROIMAGE, 220  Author URL.
Mertens LJ, Wall MB, Roseman L, Demetriou L, Nutt DJ, Carhart-Harris RL (2020). Therapeutic mechanisms of psilocybin: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression. JOURNAL OF PSYCHOPHARMACOLOGY, 34(2), 167-180.  Author URL.
Girn M, Mills C, Roseman L, Carhart-Harris RL, Christoff K (2020). Updating the dynamic framework of thought: Creativity and psychedelics. NEUROIMAGE, 213  Author URL.
Lord L-D, Expert P, Atasoy S, Roseman L, Rapuano K, Lambiotte R, Nutt DJ, Deco G, Carhart-Harris RL, Kringelbach ML, et al (2019). Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin. NEUROIMAGE, 199, 127-142.  Author URL.
Roseman L, Haijen E, Idialu-Ikato K, Kaelen M, Watts R, Carhart-Harris R (2019). Emotional breakthrough and psychedelics: Validation of the Emotional Breakthrough Inventory. JOURNAL OF PSYCHOPHARMACOLOGY, 33(9), 1076-1087.  Author URL.
Timmermann C, Roseman L, Schartner M, Milliere R, Williams LTJ, Erritzoe D, Muthukumaraswamy S, Ashton M, Bendrioua A, Kaur O, et al (2019). Neural correlates of the DMT experience assessed with multivariate EEG. SCIENTIFIC REPORTS, 9  Author URL.
Timmermann C, Roseman L, Williams L, Erritzoe D, Martial C, Cassol H, Laureys S, Nutt D, Carhart-Harris R (2018). DMT Models the Near-Death Experience. FRONTIERS IN PSYCHOLOGY, 9  Author URL.
Erritzoe D, Roseman L, Nour MM, MacLean K, Kaelen M, Nutt DJ, Carhart-Harris RL (2018). Effects of psilocybin therapy on personality structure. Acta Psychiatrica Scandinavica, 138(5), 368-378. Abstract.
Roseman L, Demetriou L, Wall MB, Nutt DJ, Carhart-Harris RL (2018). Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression. NEUROPHARMACOLOGY, 142, 263-269.  Author URL.
Haijen ECHM, Kaelen M, Roseman L, Timmermann C, Kettner H, Russ S, Nutt D, Daws RE, Hampshire ADG, Lorenz R, et al (2018). Predicting Responses to Psychedelics: a Prospective Study. FRONTIERS IN PHARMACOLOGY, 9  Author URL.
Carhart-Harris RL, Roseman L, Haijen E, Erritzoe D, Watts R, Branchi I, Kaelen M (2018). Psychedelics and the essential importance of context. JOURNAL OF PSYCHOPHARMACOLOGY, 32(7), 725-731.  Author URL.
Milliere R, Carhart-Harris RL, Roseman L, Trautwein F-M, Berkovich-Ohana A (2018). Psychedelics, Meditation, and Self-Consciousness. FRONTIERS IN PSYCHOLOGY, 9  Author URL.
Roseman L, Nutt DJ, Carhart-Harris RL (2018). Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression. FRONTIERS IN PHARMACOLOGY, 8  Author URL.
Hendler T, Raz G, Shimrit S, Jacob Y, Lin T, Roseman L, Wahid WM, Kremer I, Kupchik M, Kotler M, et al (2018). Social affective context reveals altered network dynamics in schizophrenia patients. TRANSLATIONAL PSYCHIATRY, 8  Author URL.
Kaelen M, Giribaldi B, Raine J, Evans L, Timmerman C, Rodriguez N, Roseman L, Feilding A, Nutt D, Carhart-Harris R, et al (2018). The hidden therapist: evidence for a central role of music in psychedelic therapy. PSYCHOPHARMACOLOGY, 235(2), 505-519.  Author URL.
Kaelen M, Giribaldi B, Raine J, Evans L, Timmermann C, Rodriguez N, Roseman L, Feilding A, Nutt D, Carhart-Harris R, et al (2018). The hidden therapist: evidence for a central role of music in psychedelic therapy (vol 235, pg 505, 2018). PSYCHOPHARMACOLOGY, 235(5), 1623-1623.  Author URL.
Walpola IC, Nest T, Roseman L, Erritzoe D, Feilding A, Nutt DJ, Carhart-Harris RL (2017). Altered Insula Connectivity under MDMA. NEUROPSYCHOPHARMACOLOGY, 42(11), 2152-2162.  Author URL.
Atasoy S, Roseman L, Kaelen M, Kringelbach ML, Deco G, Carhart-Harris RL (2017). Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. SCIENTIFIC REPORTS, 7  Author URL.
Carhart-Harris RL, Roseman L, Bolstridge M, Demetriou L, Pannekoek JN, Wall MB, Tanner M, Kaelen M, McGonigle J, Murphy K, et al (2017). Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. SCIENTIFIC REPORTS, 7  Author URL.
Tagliazucchi E, Roseman L, Kaelen M, Orban C, Muthukumaraswamy SD, Murphy K, Laufs H, Leech R, McGonigle J, Crossley N, et al (2016). Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Curr Biol, 26(8), 1043-1050. Abstract.  Author URL.
Roseman L, Sereno MI, Leech R, Kaelen M, Orban C, McGonigle J, Feilding A, Nutt DJ, Carhart-Harris RL (2016). LSD Alters Eyes-Closed Functional Connectivity within the Early Visual Cortex in a Retinotopic Fashion. HUMAN BRAIN MAPPING, 37(8), 3031-3040.  Author URL.
Roseman L, Sereno M, Leech R, Kaelen M, Orban C, McGonigle J, Feilding A, Nutt D, Carhart-Harris R (2016). LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion. Journal of Vision, 16(12).
Kaelen M, Roseman L, Kahan J, Santos-Ribeiro A, Orban C, Lorenz R, Barrett FS, Bolstridge M, Williams T, Williams L, et al (2016). LSD modulates music-induced imagery via changes in parahippocampal connectivity. Eur Neuropsychopharmacol, 26(7), 1099-1109. Abstract.  Author URL.
Carhart-Harris RL, Muthukumaraswamy S, Roseman L, Kaelen M, Droog W, Murphy K, Tagliazucchi E, Schenberg EE, Nest T, Orban C, et al (2016). Neural correlates of the LSD experience revealed by multimodal neuroimaging. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(17), 4853-4858.  Author URL.
Kaelen M, Barrett FS, Roseman L, Lorenz R, Family N, Bolstridge M, Curran HV, Feilding A, Nutt DJ, Carhart-Harris RL, et al (2015). LSD enhances the emotional response to music. Psychopharmacology (Berl), 232(19), 3607-3614. Abstract.  Author URL.
Carhart-Harris RL, Murphy K, Leech R, Erritzoe D, Wall MB, Ferguson B, Williams LTJ, Roseman L, Brugger S, De Meer I, et al (2015). The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity. BIOLOGICAL PSYCHIATRY, 78(8), 554-562.  Author URL.
Lerner Y, Madah W, Bleich-Cohen M, Roseman L, Solnik S, Yogev-Seligmann G, Hendler T, Kremer I (2014). EPA-0414 – Breakdown of temporal hierarchy in neural processing of natural information: evidence from schizophrenia. European Psychiatry, 29
Roseman L, Leech R, Feilding A, Nutt DJ, Carhart-Harris RL (2014). The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers. FRONTIERS IN HUMAN NEUROSCIENCE, 8  Author URL.

Conferences

Kanen J, Luppi A, Luo Q, Roseman L, Cardinal R, Robbins T, Nutt D, Den Ouden H, Carhart-Harris R (2021). Neural and Behavioural Evidence from Reinforcement Learning Converge in Support of Relaxed Beliefs Under LSD.  Author URL.
Wall M, Lam C, Ertl N, Kaelen M, Roseman L, Nutt D, Carhart-Harris R (2021). The effect of psilocybin therapy for depression on low-frequency brain activity in response to music.  Author URL.
Mertens LJ, Wall MB, Roseman L, Demetriou L, Nutt DJ, Carhart-Harris RL (2019). Therapeutic mechanisms of psychedelic drugs: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression.  Author URL.
Kaelen M, Roseman L, Lebedev A, Kahan J, Santos-Ribeiro A, Orban C, Lorenz R, Nutt D, Carhart-Harris R (2016). Effects of LSD and music on brain activity.  Author URL.
Kaelen M, Roseman L, Lorenz R, Simmonds A, Santos-Ribeiro A, Nutt D, Carhart-Harris R (2016). Effects of LSD and music on brain activity.  Author URL.

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